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Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy.
Li, Xia; Cai, Qin-Yu; Luo, Xin; Wang, Yong-Heng; Shao, Li-Zhen; Luo, Shu-Juan; Wang, Lan; Wang, Ying-Xiong; Lan, Xia; Liu, Tai-Hang.
Afiliación
  • Li X; Department of Bioinformatics, School of Basic Medical Sciences , Chongqing Medical University, No.1 Yixueyuan Rd, Yuzhong District, 400016, Chongqing, China.
  • Cai QY; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, 400016, Chongqing, China.
  • Luo X; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, 400016, Chongqing, China.
  • Wang YH; Department of Obstetrics, Women and Children's Hospital of Chongqing Medical University, 401147, Chongqing, China.
  • Shao LZ; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, 400016, Chongqing, China.
  • Luo SJ; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
  • Wang L; Department of Bioinformatics, School of Basic Medical Sciences , Chongqing Medical University, No.1 Yixueyuan Rd, Yuzhong District, 400016, Chongqing, China.
  • Wang YX; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, 400016, Chongqing, China.
  • Lan X; Department of Bioinformatics, School of Basic Medical Sciences , Chongqing Medical University, No.1 Yixueyuan Rd, Yuzhong District, 400016, Chongqing, China.
  • Liu TH; Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, 400016, Chongqing, China.
Diabetol Metab Syndr ; 16(1): 57, 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38429774
ABSTRACT

PURPOSE:

To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP.

METHODS:

This multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all subjects were collected from hospital electronic medical records. Univariate and multivariate logistic regression analysis were used to compare the incidence of perinatal outcomes between ICP with GDM group and ICP alone group.

RESULTS:

Baseline characteristics of the population revealed that maternal age (p < 0.001), pregestational weight (p = 0.01), pre-pregnancy BMI (p < 0.001), gestational weight gain (p < 0.001), assisted reproductive technology (ART) (p < 0.001), and total bile acid concentration (p = 0.024) may be risk factors for ICP with GDM. Furthermore, ICP with GDM demonstrated a higher association with both polyhydramnios (OR 2.66) and preterm labor (OR 1.67) compared to ICP alone. Further subgroup analysis based on the severity of ICP showed that elevated total bile acid concentrations were closely associated with an increased risk of preterm labour, meconium-stained amniotic fluid, and low birth weight in both ICP alone and ICP with GDM groups. ICP with GDM further worsened these outcomes, especially in women with severe ICP. The nomogram prediction model effectively predicted the occurrence of preterm labour in the ICP population.

CONCLUSIONS:

ICP with GDM may result in more adverse pregnancy outcomes, which are associated with bile acid concentrations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetol Metab Syndr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetol Metab Syndr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido