Efficacy of the traditional Chinese medicine, Buyang Huanwu Decoction, at preventing taxane-induced peripheral neuropathy in breast cancer patients: A prospective, randomized, controlled study.
Medicine (Baltimore)
; 103(9): e37338, 2024 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-38428887
ABSTRACT
BACKGROUND:
Buyang Huanwu Decoction (BYHWD) is a traditional Chinese prescription, originally derived from Yi Lin Gai Cuo during the Qing Dynasty. This study aimed to evaluate the efficacy and safety of BYHWD in the prevention of taxane-induced peripheral neuropathy (TIPN) in patients with breast cancer.METHODS:
This single-center, statistician-blinded, parallel-group, simple randomized, no-treatment controlled study was conducted at the China-Japan Friendship Hospital in Beijing. Sixty breast cancer patients scheduled to receive nab-paclitaxel-based chemotherapy were randomly assigned to either the BYHWD group (Nâ =â 30) or the control group (Nâ =â 30) using simple randomization procedures. The data analysts were unaware of the treatment allocation. The primary efficacy endpoints were the incidence and severity of TIPN in the 2 groups, assessed using the Common Terminology Criteria for Adverse Events (CTCAE) and Patients' Neurotoxicity Questionnaire (PNQ). The secondary efficacy endpoint was the score of Functional Assessment of Cancer Therapy-Breast for both groups. The primary safety endpoints were routine blood test results and liver and renal functions. Both groups were subjected to 4 chemotherapy cycles. Efficacy and safety analyses were conducted on an intention-to-treat basis.RESULTS:
The incidence of TIPN in the BYHWD group was 50.0%, which was lower than the 80.0% incidence in the control group (ßâ =â -1.881 [95%CI -3.274, -.488]; Pâ =â .008, adjusted). The probability of TIPN in the BYHWD group was 15.2% of that in the control group, representing a significant reduction in incidence (odds ratioâ =â .152, [95%CI .038, 0.614]; Pâ =â .008, adjusted). The CTCAE and PNQ grades of the BYHWD group were 1.527 and 1.495 points lower than those of the control group at the same cycle, respectively (CTCAE ßâ =â -1.527 [95%CI -2.522, -.533]; Pâ =â .003, adjusted; PNQ ßâ =â -1.495 [95%CI -2.501, -.489]; Pâ =â .004, adjusted, respectively). After treatment, the Functional Assessment of Cancer Therapy-Breast scores in the BYHWD group were significantly better than those in the control group (Pâ =â .003), especially in the physiological, functional, and additional concerns domains.CONCLUSION:
Buyang Huanwu decoction (BYHWD) can effectively prevent TIPN and improve the quality of life in patients with breast cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Hidrocarburos Aromáticos con Puentes
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Medicamentos Herbarios Chinos
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Enfermedades del Sistema Nervioso Periférico
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Síndromes de Neurotoxicidad
Límite:
Female
/
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos