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Atlas of exercise-induced brain activation in mice.
Skovbjerg, Grethe; Fritzen, Andreas Mæchel; Svendsen, Charlotte Sashi Aier; Perens, Johanna; Skytte, Jacob Lercke; Lund, Camilla; Lund, Jens; Madsen, Martin Rønn; Roostalu, Urmas; Hecksher-Sørensen, Jacob; Clemmensen, Christoffer.
Afiliación
  • Skovbjerg G; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Gubra, Hørsholm, Denmark.
  • Fritzen AM; August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Svendsen CSA; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Perens J; Gubra, Hørsholm, Denmark.
  • Skytte JL; Gubra, Hørsholm, Denmark.
  • Lund C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Lund J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Madsen MR; Gubra, Hørsholm, Denmark.
  • Roostalu U; Gubra, Hørsholm, Denmark.
  • Hecksher-Sørensen J; Gubra, Hørsholm, Denmark.
  • Clemmensen C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: chc@sund.ku.dk.
Mol Metab ; 82: 101907, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38428817
ABSTRACT

OBJECTIVES:

There is significant interest in uncovering the mechanisms through which exercise enhances cognition, memory, and mood, and lowers the risk of neurodegenerative diseases. In this study, we utilize forced treadmill running and distance-matched voluntary wheel running, coupled with light sheet 3D brain imaging and c-Fos immunohistochemistry, to generate a comprehensive atlas of exercise-induced brain activation in mice.

METHODS:

To investigate the effects of exercise on brain activity, we compared whole-brain activation profiles of mice subjected to treadmill running with mice subjected to distance-matched wheel running. Male mice were assigned to one of four groups a) an acute bout of voluntary wheel running, b) confinement to a cage with a locked running wheel, c) forced treadmill running, or d) placement on an inactive treadmill. Immediately following each exercise or control intervention, blood samples were collected for plasma analysis, and brains were collected for whole-brain c-Fos quantification.

RESULTS:

Our dataset reveals 255 brain regions activated by acute exercise in mice, the majority of which have not previously been linked to exercise. We find a broad response of 140 regulated brain regions that are shared between voluntary wheel running and treadmill running, while 32 brain regions are uniquely regulated by wheel running and 83 brain regions uniquely regulated by treadmill running. In contrast to voluntary wheel running, forced treadmill running triggers activity in brain regions associated with stress, fear, and pain.

CONCLUSIONS:

Our findings demonstrate a significant overlap in neuronal activation signatures between voluntary wheel running and distance-matched forced treadmill running. However, our analysis also reveals notable differences and subtle nuances between these two widely used paradigms. The comprehensive dataset is accessible online at www.neuropedia.dk, with the aim of enabling future research directed towards unraveling the neurobiological response to exercise.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Actividad Motora Límite: Animals Idioma: En Revista: Mol Metab Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Actividad Motora Límite: Animals Idioma: En Revista: Mol Metab Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Alemania