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Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting.
De Spiegeleer, Anton; Descamps, Amélie; Wynendaele, Evelien; Naumovski, Petar; Crombez, Liesbeth; Planas, Marta; Feliu, Lidia; Knappe, Daniel; Mouly, Vincent; Bigot, Anne; Bielza, Rafael; Hoffmann, Ralf; Van Den Noortgate, Nele; Elewaut, Dirk; De Spiegeleer, Bart.
Afiliación
  • De Spiegeleer A; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Department of Geriatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium.
  • Descamps A; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Wynendaele E; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Naumovski P; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
  • Crombez L; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Department of Geriatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium.
  • Planas M; LIPPSO, Department of Chemistry, Universitat de Girona, Maria Aurèlia Capmany 69, Girona, Spain.
  • Feliu L; LIPPSO, Department of Chemistry, Universitat de Girona, Maria Aurèlia Capmany 69, Girona, Spain.
  • Knappe D; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
  • Mouly V; Centre de Recherche en Myologie, Sorbonne Université, Paris, France.
  • Bigot A; Centre de Recherche en Myologie, Sorbonne Université, Paris, France.
  • Bielza R; Department of Geriatric Medicine, Hospital Universitario Infanta Sofía, Madrid, Spain.
  • Hoffmann R; Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany; Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
  • Van Den Noortgate N; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Department of Geriatrics, Faculty of Medicine and Health Sciences, Ghent University Hospital, Ghent, Belgium.
  • Elewaut D; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Center, Unit for Molecular Immunology and Inflammation, Ghent University, Ghent, Belgium; Department of Rheumatology, Faculty of Medicine and Hea
  • De Spiegeleer B; Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium; Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address: bart.despiegeleer@ugent.be.
Biochim Biophys Acta Mol Basis Dis ; 1870(4): 167094, 2024 04.
Article en En | MEDLINE | ID: mdl-38428683
ABSTRACT
Muscle wasting diseases, such as cancer cachexia and age-associated sarcopenia, have a profound and detrimental impact on functional independence, quality of life, and survival. Our understanding of the underlying mechanisms is currently limited, which has significantly hindered the development of targeted therapies. In this study, we explored the possibility that the streptococcal quorum sensing peptide Competence Stimulating Peptide 7 (CSP-7) might be a previously unidentified contributor to clinical muscle wasting. We found that CSP-7 selectively triggers muscle cell inflammation in vitro, specifically the release of IL-6. Furthermore, we demonstrated that CSP-7 can traverse the gastrointestinal barrier in vitro and is present in the systemic circulation in humans in vivo. Importantly, CSP-7 was associated with a muscle wasting phenotype in mice in vivo. Overall, our findings provide new mechanistic insights into the pathophysiology of muscle inflammation and wasting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caquexia / Percepción de Quorum Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caquexia / Percepción de Quorum Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Países Bajos