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In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model.
Diogo, Gabriela S; Permuy, María; Marques, Catarina F; Sotelo, Cármen G; Pérez-Martín, Ricardo I; Serra, Julia; González, Pio; Munõz, Fernando; Pirraco, Rogério P; Reis, Rui L; Silva, Tiago H.
Afiliación
  • Diogo GS; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barc
  • Permuy M; Dpto. Anatomía, Producción animal e Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Av Carvallo Calero s/n, 27002 Lugo, Spain; iBoneLab SL, Av da Coruña 500, 27003 Lugo, Spain.
  • Marques CF; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barc
  • Sotelo CG; Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, Spain.
  • Pérez-Martín RI; Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, Spain.
  • Serra J; CINTECX, Universidade de Vigo, Grupo de Novos Materiais, 36310 Vigo, Spain; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain.
  • González P; CINTECX, Universidade de Vigo, Grupo de Novos Materiais, 36310 Vigo, Spain; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain.
  • Munõz F; Dpto. Anatomía, Producción animal e Ciencias Clínicas Veterinarias, Universidade de Santiago de Compostela, Av Carvallo Calero s/n, 27002 Lugo, Spain; iBoneLab SL, Av da Coruña 500, 27003 Lugo, Spain.
  • Pirraco RP; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barc
  • Reis RL; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barc
  • Silva TH; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barc
Biomater Adv ; 159: 213813, 2024 May.
Article en En | MEDLINE | ID: mdl-38428122
ABSTRACT
The ability of human tissues to self-repair is limited, which motivates the scientific community to explore new and better therapeutic approaches to tissue regeneration. The present manuscript provides a comparative study between a marine-based composite biomaterial, and another composed of well-established counterparts for bone tissue regeneration. Blue shark skin collagen was combined with bioapatite obtained from blue shark's teeth (mCollBAp), while bovine collagen was combined with synthetic hydroxyapatite (bCollAp) to produce 3D composite scaffolds by freeze-drying. Collagens showed similar profiles, while apatite particles differed in their composition, being the marine bioapatite a fluoride-enriched ceramic. The marine-sourced biomaterials presented higher porosities, improved mechanical properties, and slower degradation rates when compared to synthetic apatite-reinforced bovine collagen. The in vivo performance regarding bone tissue regeneration was evaluated in defects created in femoral condyles in New Zealand rabbits twelve weeks post-surgery. Micro-CT results showed that mCollBAp implanted condyles had a slower degradation and an higher tissue formation (17.9 ± 6.9 %) when compared with bCollAp implanted ones (12.9 ± 7.6 %). The histomorphometry analysis provided supporting evidence, confirming the observed trend by quantifying 13.1 ± 7.9 % of new tissue formation for mCollBAp composites and 10.4 ± 3.2 % for bCollAp composites, suggesting the potential use of marine biomaterials for bone regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Andamios del Tejido Límite: Animals / Humans Idioma: En Revista: Biomater Adv Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Andamios del Tejido Límite: Animals / Humans Idioma: En Revista: Biomater Adv Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos