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Mechanical Stress Via Muscle Contractile Exercise Suppresses Atrophic Alterations of Bone-microstructure in Immobilized Rat Femurs.
Kajiwara, Yasuhiro; Honda, Yuichiro; Takahashi, Ayumi; Tanaka, Natsumi; Koseki, Hironobu; Sakamoto, Junya; Okita, Minoru.
Afiliación
  • Kajiwara Y; Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Honda Y; Department of Rehabilitation, Nagasaki University Hospital, Nagasaki, Japan.
  • Takahashi A; Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Tanaka N; Institute of Biomedical Sciences (Health Sciences), Nagasaki University, Nagasaki, Japan.
  • Koseki H; Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  • Sakamoto J; Department of Physical Therapy, School of Rehabilitation Sciences, Seirei Christopher University, Shizuoka, Japan.
  • Okita M; Department of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Musculoskelet Neuronal Interact ; 24(1): 22-30, 2024 Mar 01.
Article en En | MEDLINE | ID: mdl-38427365
ABSTRACT

OBJECTIVES:

This study aimed to determine whether mechanical stress via muscle contractile exercise with belt electrode-skeletal muscle electrical stimulation (B-SES) device effectively prevents immobilization-induced bone atrophy.

METHODS:

Wistar rats were randomly divided into the control (CON) group, immobilization (IM) group (immobilized treatment only), HES and LES groups (immobilized treatment and high or low-intensity electrical muscular stimulation through B-SES device). Bilateral femurs were used for X-ray micro-CT and biomechanical tests.

RESULTS:

The maximum load value was significantly lower in the IM and HES groups than in the CON group and significantly higher in the LES group than in the IM group. The maximum crushing load was significantly lower in the IM, HES, and LES groups than in the CON group, and significantly higher in the HES and LES groups than that in the IM group. In micro-CT, the mechanical stress by B-SES device did not affect degenerative microstructural changes in the cortical bone, but prevented those changes in the cancellous bone.

CONCLUSIONS:

Applying mechanical stress via B-SES device suppressed the loss of cancellous bone density and degenerative microstructural changes caused by immobilization, which in turn suppressed the reduction of bone strength. From these findings, muscle contractile exercise may be effective in preventing immobilization-induced bone atrophy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Huesos / Músculo Esquelético Límite: Animals Idioma: En Revista: J Musculoskelet Neuronal Interact Asunto de la revista: FISIOLOGIA / NEUROLOGIA / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Huesos / Músculo Esquelético Límite: Animals Idioma: En Revista: J Musculoskelet Neuronal Interact Asunto de la revista: FISIOLOGIA / NEUROLOGIA / ORTOPEDIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia