Your browser doesn't support javascript.
loading
Fecal Microbiota Transplantation in Amyotrophic Lateral Sclerosis: Clinical Protocol and Evaluation of Microbiota Immunity Axis.
Niccolai, Elena; Martinelli, Ilaria; Quaranta, Gianluca; Nannini, Giulia; Zucchi, Elisabetta; De Maio, Flavio; Gianferrari, Giulia; Bibbò, Stefano; Cammarota, Giovanni; Mandrioli, Jessica; Masucci, Luca; Amedei, Amedeo.
Afiliación
  • Niccolai E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • Martinelli I; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
  • Quaranta G; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
  • Nannini G; Department of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, Rome, Italy.
  • Zucchi E; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
  • De Maio F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Gianferrari G; Department of Laboratory and Infectious Sciences, A. Gemelli University Hospital IRCCS, Rome, Italy.
  • Bibbò S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Cammarota G; Digestive Disease Center, A. Gemelli University Hospital IRCCS, Catholic University of Sacred Heart, Rome, Italy.
  • Mandrioli J; Digestive Disease Center, A. Gemelli University Hospital IRCCS, Catholic University of Sacred Heart, Rome, Italy.
  • Masucci L; Neurology Unit, Department of Neuroscience, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
  • Amedei A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Methods Mol Biol ; 2761: 373-396, 2024.
Article en En | MEDLINE | ID: mdl-38427251
ABSTRACT
The fecal microbial transplantation (FMT) is a therapeutic transplant of fecal microbiota from healthy donors to patients. This practice is aimed at restoring eubiosis and rebalancing the enteric and systemic immune responses, and then eliminating pathogenic triggers of multiple disease, including neurodegenerative diseases. Alterations of gut microbiota (GM) affect the central nervous system (CNS) health, impacting neuro-immune interactions, synaptic plasticity, myelination, and skeletal muscle function. T-regulatory lymphocytes (Treg) are among the most important players in the pathogenesis of amyotrophic lateral sclerosis (ALS), altering the disease course. Along with circulating neuropeptides, other immune cells, and the gut-brain axis, the GM influences immunological tolerance and controls Treg's number and suppressive functions. A double-blind, controlled, multicenter study on FMT in ALS patients has been designed to evaluate if FMT can modulate neuroinflammation, by restoring Treg number, thus modifying disease activity and progression.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbiota / Microbioma Gastrointestinal / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microbiota / Microbioma Gastrointestinal / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos