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TyG-GGT is a Reliable Non-Invasive Predictor of Advanced Liver Fibrosis in Overweight or Obese Individuals.
Jin, Lei; Gu, Jing; Zhang, Zhe; Du, Cheng-Fei; Xu, Fei-Qi; Huang, Xiao-Kun; Gao, Zhen-Yu; Li, Ying; Yu, Li-Li; Zhang, Xin; Ru, Guo-Qing; Liu, Jun-Wei; Liang, Lei; Sun, Xiao-Dong; Xiao, Zun-Qiang.
Afiliación
  • Jin L; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Gu J; The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
  • Zhang Z; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Du CF; The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
  • Xu FQ; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Huang XK; The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
  • Gao ZY; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Li Y; The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
  • Yu LL; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Zhang X; The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
  • Ru GQ; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Liu JW; Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, China.
  • Liang L; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
  • Sun XD; Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, China.
  • Xiao ZQ; General Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
Obes Surg ; 34(4): 1333-1342, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38427150
ABSTRACT

BACKGROUND:

Liver fibrosis is a predisposing factor for liver cancer. This study will investigate the predictive role of the Triglyceride-glucose and Gamma-glutamyl transferase index (TyG-GGT) as a non-invasive indicator of advanced liver fibrosis in individuals with obesity or overweight.

METHOD:

We enrolled patients who underwent metabolic and bariatric surgery as well as intraoperative liver biopsies at Zhejiang provincial people's hospital from August 2020 to March 2023. Clinical characteristics, comorbidities, laboratory data, and pathological variables of patients were collected and analysed. Then, we conducted logistics regression model to compare the performance of the TyG-GGT index with other 4 non-invasive models.

RESULTS:

A total of 65 patients were included in this study. 43(66.2%) of them were female, with the mean body mass index (BMI) of 39.0 ± 7.3 kg/m2. Meanwhile, 24(36.9%) patients were diagnosed with diabetes. Advanced liver fibrosis were observed in 16.9% of patients, while liver cirrhosis was found in 4.6% of patients. The multivariable logistics regression showed that TyG-GGT was an independent risk factor of advanced liver fibrosis (OR = 6.989, P = 0.049). Additionally, compared to another 4 non-invasive liver fibrosis models (NFS = 0.66, FIB4 = 0.65, METS-IR = 0.68, APRI = 0.65), TyG-GGT exhibits the highest AUC value of 0.75.

CONCLUSIONS:

More than one-third of patients undergoing metabolic and bariatric surgery are afflicted with nonalcoholic steatohepatitis (NASH), and a significant proportion exhibit advanced fibrosis. TyG-GGT was a potentially reliable predictor for screening individuals with overweight or obesity at high risk of advanced liver fibrosis, thus providing clinical guidance for early intervention in this targeted group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triglicéridos / Glucemia / Gamma-Glutamiltransferasa / Cirrosis Hepática Límite: Female / Humans / Male Idioma: En Revista: Obes Surg Asunto de la revista: METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triglicéridos / Glucemia / Gamma-Glutamiltransferasa / Cirrosis Hepática Límite: Female / Humans / Male Idioma: En Revista: Obes Surg Asunto de la revista: METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos