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Prevalence and Associated Clinical Characteristics of Walking-Related Motor, Cognitive, and Fatigability in Progressive Multiple Sclerosis: Baseline Results From the CogEx Study.
Ramari, Cintia; D'hooge, Mieke; Dalgas, Ulrik; Feinstein, Anthony; Amato, Maria Pia; Brichetto, Giampaolo; Chataway, Jeremy; Chiaravalloti, Nancy D; Cutter, Gary R; DeLuca, John; Farrell, Rachel; Filippi, Massimo; Freeman, Jennifer; Inglese, Matilde; Meza, Cecilia; Motl, Robert W; Rocca, Maria A; Sandroff, Brian M; Salter, Amber; Kos, Daphne; Feys, Peter.
Afiliación
  • Ramari C; REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Limburg, Belgium.
  • D'hooge M; UMSC University MS Center Hasselt Pelt, Hasselt Pelt, Belgium.
  • Dalgas U; REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Limburg, Belgium.
  • Feinstein A; National MS Center, Melsbroek, Belgium.
  • Amato MP; Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
  • Brichetto G; Department of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Chataway J; Department NEUROFARBA, Section Neurosciences, University of Florence, Florence, Italy.
  • Chiaravalloti ND; IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
  • Cutter GR; Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy.
  • DeLuca J; AISM Rehabilitation Service, Italian Multiple Sclerosis Society, Genoa, Italy.
  • Farrell R; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
  • Filippi M; National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, UK.
  • Freeman J; Kessler Foundation, East Hanover, NJ, USA.
  • Inglese M; Department of Physical Medicine & Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Meza C; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Motl RW; Kessler Foundation, East Hanover, NJ, USA.
  • Rocca MA; Department of Physical Medicine & Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA.
  • Sandroff BM; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
  • Salter A; National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, UK.
  • Kos D; Neuroimaging Research Unit, Institute of Experimental Neurology, IRCSS San Raffaele Scientific Institute, Milan, Italy.
  • Feys P; Neurology Unit, IRCSS San Raffaele Scientific Institute, Milan, Italy.
Neurorehabil Neural Repair ; 38(5): 327-338, 2024 May.
Article en En | MEDLINE | ID: mdl-38426484
ABSTRACT

BACKGROUND:

People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is objectively measured by the capacity to sustain a motor or cognitive task.

OBJECTIVE:

To investigate the prevalence of walking and cognitive fatigability (CF) and the associated clinical characteristics in a large sample of PMS patients.

METHODS:

PMS patients (25-65 years old) were included from 11 sites (Europe and North America), having cognitive impairment (1.28 standard deviation below normative data for the symbol digit modality test [SDMT]). Walking fatigability (WF) was assessed using the distance walk index (DWI) and CF using the SDMT (scores from the last 30 seconds compared to the first 30 seconds). Additional measures were cognitive assessment-Brief International Cognitive Assessment for multiple sclerosis (MS), cardiorespiratory fitness, 6-minute walk, physical activity, depressive symptoms, perceived fatigue-Modified Fatigue Impact Scale (MFIS), MS impact-MSIS-29, and walking ability.

RESULTS:

Of 298 participants, 153 (51%) presented WF (DWI = -28.9 ± 22.1%) and 196 (66%) presented CF (-29.7 ± 15%). Clinical characteristics (EDSS, disease duration, and use of assistive device) were worse in patients with versus without WF. They also presented worse scores on MSIS-29 physical, MFIS total and physical and reduced physical capacity. CF patients scored better in the MSIS-29 physical and MFIS psychosocial, compared to non-CF group. Magnitude of CF and WF were not related.

CONCLUSIONS:

Half of the cognitively-impaired PMS population presented WF which was associated with higher disability, physical functions, and fatigue. There was a high prevalence of CF but without strong associations with clinical, cognitive, and physical functions. TRIAL REGISTRATION NUMBER The "CogEx-study," www.clinicaltrial.gov identifier number NCT03679468.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caminata / Esclerosis Múltiple Crónica Progresiva / Fatiga / Disfunción Cognitiva Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurorehabil Neural Repair Asunto de la revista: NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caminata / Esclerosis Múltiple Crónica Progresiva / Fatiga / Disfunción Cognitiva Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurorehabil Neural Repair Asunto de la revista: NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos