Evaluation of risk factors for recurrence of cutaneous adverse reactions due to anti-seizure medications in children: A retrospective study.
Curr J Neurol
; 22(4): 210-216, 2023 Oct 07.
Article
en En
| MEDLINE
| ID: mdl-38425358
ABSTRACT
Background:
Cutaneous adverse reactions (CARs) are one of the most important reasons for anti-seizure medication (ASM) discontinuation in epilepsy. However, such discontinuations can cause an increase in seizures. This study investigates the risk factors for ASM-related rash recurrence in children.Methods:
This retrospective case-control study consisted of the patient group with a single rash due to ASMs (group 1), the patient group with rash recurrence (group 2), and the control group. While the demographic and clinical features of group 1 and the control group were compared in terms of a single rash, group 1 and group 2 were compared for rash recurrence.Results:
Group 1, group 2, and control group consisted of 112, 33, and 166 patients, respectively. Female gender was a risk factor for a single rash (P < 0.001) but not for recurrence (P = 0.439). Presence of atopic disease [odds ratio (OR) 9.5, 95% confidence interval (CI) 3.8-23.1, P < 0.001], family history of drug allergy (OR 26.3, 95% CI 9.6-72.1, P < 0.001), and polytherapy (OR 23.5, 95% CI 8.7-62.9, P < 0.001) were risk factors for rash recurrence. Aromatic nature of both the ASMs associated with the first rash (OR 14.4, 95% CI 3.2-63.2, P < 0.001) and rash recurrence (OR 11.3, 95% CI 4.6-27.5, P < 0.001) were determined as risk factors separately.Conclusion:
Careful use of aromatic drugs may prevent recurrence of ASM-related CAR in children, particularly in cases of personal history of allergic disease and family history of drug allergy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Curr J Neurol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Irán