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Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals.
Zhu, Bowen; Li, Fang; Zhang, Weidong; Zhao, Shuan; Song, Nana; Jin, Shi; Shen, Ziyan; Lu, Yufei; Li, Yang; Liu, Hong.
Afiliación
  • Zhu B; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Li F; Shanghai Medical Center of Kidney, Shanghai, China.
  • Zhang W; Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China.
  • Zhao S; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Song N; Shanghai Medical Center of Kidney, Shanghai, China.
  • Jin S; Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China.
  • Shen Z; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
  • Lu Y; Shanghai Medical Center of Kidney, Shanghai, China.
  • Li Y; Shanghai Key Laboratory of Kidney and Blood Purification, Shanghai, China.
  • Liu H; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Ren Fail ; 46(1): 2301041, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38425055
ABSTRACT

INTRODUCTION:

Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population. MATERIALS AND

METHODS:

The study included 4180 individuals aged 45-85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015. Additionally, a hospital-based study enrolled subjects in the Department of Nephrology at Zhongshan Hospital, China from January 1, 2019, to December 31, 2021. The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. For the hospital-based population, kidney injury was marked by a KIM-1 positive area.

RESULTS:

Our results indicate a higher prevalence of CKD in the community population with hypertension (10.2% vs. 3.9%, p < .001). A significant additive synergistic effects of the sUA and hypertension on the CKD risk were found. When the sUA level was < 4.55 mg/dL in the hypertensive population and < 5.58 mg/dL in the non-hypertensive population, the risk of CKD was comparable (p = .809). In the propensity score matched (PSM) population, the result remained roughly constant.

CONCLUSION:

Therefore, even moderate levels of sUA was associated with a higher risk of CKD in middle-aged hypertensive patients, who warrant stricter sUA control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Hipertensión Límite: Humans / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Hipertensión Límite: Humans / Middle aged Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido