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The Unveiling of Therapeutic Targets for Alzheimer's Disease: An Integrative Review.
Madar, Pratiksha; Nagalapur, Pooja; Chaudhari, Somdatta; Sharma, Devesh; Koparde, Akshada; Buchade, Rahul; Kshirsagar, Sandip; Uttekar, Pravin; Jadhav, Shailaja; Chaudhari, Praveen.
Afiliación
  • Madar P; Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India.
  • Nagalapur P; Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India.
  • Chaudhari S; Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India.
  • Sharma D; Department of Biotechnology, National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India.
  • Koparde A; Department of Pharmaceutical Chemistry, Krishna Foundation's Jaywant Institute of Pharmacy, Malkapur, Karad, India.
  • Buchade R; Department of Pharmaceutical Chemistry, Indira College of Pharmacy, Tathwade, Pune, India.
  • Kshirsagar S; Department of Pharmaceutical Chemistry, Dr. D Y Patil College of Pharmacy, Pune, India.
  • Uttekar P; Department of Pharmacuetics, Savitribai Phule Pune University, Pune, India.
  • Jadhav S; Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India.
  • Chaudhari P; Department of Pharmaceutical Chemistry, Modern College of Pharmacy, Savitribai Phule Pune University, Pune, India.
Curr Top Med Chem ; 24(10): 850-868, 2024.
Article en En | MEDLINE | ID: mdl-38424435
ABSTRACT
Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and lifestyle factors. The primary feature is the accumulation of amyloid-- beta and tau proteins, leading to neuroinflammation, synaptic dysfunction, oxidative stress, and neuronal loss. Conventional single-target therapies have shown limited effectiveness, prompting a shift toward simultaneously addressing multiple disease-related processes. Recent advancements in AD research underscore the potential of multifaceted therapies. This review explores strategies targeting both tau aggregation and amyloid-beta, along with interventions to alleviate neuroinflammation, enhance synaptic function, and reduce oxidative stress. In conclusion, the review emphasizes the growing importance of addressing various pathways in AD treatment. A holistic approach that targets different aspects of the disease holds promise for developing effective treatments and improving the quality of life for Alzheimer's patients and their caregivers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Enfermedad de Alzheimer Límite: Animals / Humans Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Enfermedad de Alzheimer Límite: Animals / Humans Idioma: En Revista: Curr Top Med Chem Asunto de la revista: QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Emiratos Árabes Unidos