Photocatalytic Keto- and Amino-Trifluoromethylation of Alkenes.

Wang, Zheng; Lin, Jin-Hong; Xiao, Ji-Chang

Wang, Zheng; Lin, Jin-Hong; Xiao, Ji-Chang.

Afiliación

Wang Z; Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, China.
Lin JH; Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, China.
Xiao JC; Department of Chemistry, Innovative Drug Research Center, Shanghai University, 200444 Shanghai, China.

Org Lett ; 26(9): 1980-1984, 2024 Mar 08.

Article en En | MEDLINE | ID: mdl-38421197

ABSTRACT

ABSTRACT

Efforts to develop alternatives to triflic anhydride (Tf2O) as a trifluoromethylation reagent continue due to its limitations, including volatility, corrosiveness, and moisture sensitivity. Described herein is the use of a trifluoromethylsulfonylpyridinium salt (TFSP), easily obtained by a one-step reaction of Tf2O with 4-dimethylaminopyridine, as a reagent for the trifluoromethylative difunctionalization of alkenes by photoredox catalysis. DMSO and CH3CN are suitable solvents for achieving keto- and amino-trifluoromethylation of alkenes, respectively, with good functional group tolerance.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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