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Dorsal motor vagal neurons can elicit bradycardia and reduce anxiety-like behavior.
Strain, Misty M; Conley, Nicholas J; Kauffman, Lily S; Espinoza, Liliana; Fedorchak, Stephanie; Martinez, Patricia Castro; Crook, Maisie E; Jalil, Maira; Hodes, Georgia E; Abbott, Stephen B G; Güler, Ali D; Campbell, John N; Boychuk, Carie R.
Afiliación
  • Strain MM; Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Conley NJ; Department of Biology, University of Virginia, Charlottesville, VA, USA.
  • Kauffman LS; Department of Biology, University of Virginia, Charlottesville, VA, USA.
  • Espinoza L; Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Fedorchak S; Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Martinez PC; Neuroscience Undergraduate Major, University of Virginia, Charlottesville, VA, USA.
  • Crook ME; Department of Biology, University of Virginia, Charlottesville, VA, USA.
  • Jalil M; Department of Biology, University of Virginia, Charlottesville, VA, USA.
  • Hodes GE; School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
  • Abbott SBG; Department of Pharmacology, University of Virginia, Charlottesville, VA, USA.
  • Güler AD; Department of Biology, University of Virginia, Charlottesville, VA, USA.
  • Campbell JN; Department of Biology, University of Virginia, Charlottesville, VA, USA.
  • Boychuk CR; Department of Cellular and Integrative Physiology, Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
iScience ; 27(3): 109137, 2024 Mar 15.
Article en En | MEDLINE | ID: mdl-38420585
ABSTRACT
Cardiovagal neurons (CVNs) innervate cardiac ganglia through the vagus nerve to control cardiac function. Although the cardioinhibitory role of CVNs in nucleus ambiguus (CVNNA) is well established, the nature and functionality of CVNs in dorsal motor nucleus of the vagus (CVNDMV) is less clear. We therefore aimed to characterize CVNDMV anatomically, physiologically, and functionally. Optogenetically activating cholinergic DMV neurons resulted in robust bradycardia through peripheral muscarinic (parasympathetic) and nicotinic (ganglionic) acetylcholine receptors, but not beta-1-adrenergic (sympathetic) receptors. Retrograde tracing from the cardiac fat pad labeled CVNNA and CVNDMV through the vagus nerve. Using whole-cell patch-clamp, CVNDMV demonstrated greater hyperexcitability and spontaneous action potential firing ex vivo despite similar resting membrane potentials, compared to CVNNA. Chemogenetically activating DMV also caused significant bradycardia with a correlated reduction in anxiety-like behavior. Thus, DMV contains uniquely hyperexcitable CVNs and is capable of cardioinhibition and robust anxiolysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos