Shorter total sleep time is associated with lower CD4+/CD8+ T cell ratios in virally suppressed men with HIV.
Sleep Adv
; 5(1): zpae001, 2024.
Article
en En
| MEDLINE
| ID: mdl-38420256
ABSTRACT
Study Objectives:
Although poor sleep quality is associated with lower CD4+â T cell counts among people living with HIV (PLWH), the association between objective sleep metrics and T lymphocyte subset counts is unknown. We evaluated the association between polysomnography (PSG) derived sleep metrics and T lymphocyte subpopulations in a cohort of men living with HIV.Methods:
Virally suppressed men living with HIV participating in the Multicenter AIDS Cohort Study underwent home overnight PSG. We assessed the association of PSG parameters with CD4+â and CD8+â T cell counts and the CD4+/CD8+â T cell ratio.Results:
Overall, 289 men with mean (±SD) age 55.3â ±â 11.3 years and mean CD4+â T cell count 730â ±â 308 cells/mm3 were evaluated. Total sleep time (TST) was significantly associated with CD8+â but not CD4+â T cell counts. After adjusting for age, race, depressive symptoms, antidepressant use, and non-nucleoside reverse transcriptase inhibitors use, every hour of shorter TST was associated with an additional 33 circulating CD8+â T cells/mm3 (pâ =â 0.05) and a 5.6% (pâ =â 0.0007) decline in CD4+/CD8+â T cell ratio. In adjusted models, every hour of shorter rapid eye movement (REM) sleep was associated with an additional 113 CD8+â T cells/mm3 (pâ =â 0.02) and a 15.1% lower CD4+/CD8+â T cell ratio (pâ =â 0.006). In contrast, measures of sleep efficiency and sleep-disordered breathing were not associated with differences in T lymphocyte subpopulations.Conclusions:
Our findings suggest that shorter TST and REM sleep durations are associated with differences in T lymphocyte subpopulations among men living with HIV. Addressing sleep may reflect a novel opportunity to improve immune function in PLWH.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Sleep Adv
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos