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Atrial fibrillation in human patients is associated with increased collagen type V and TGFbeta1.
Kostin, Sawa; Richter, Manfred; Ganceva, Natalia; Sasko, Benjamin; Giannakopoulos, Theodoros; Ritter, Oliver; Szalay, Zoltan; Pagonas, Nikolaos.
Afiliación
  • Kostin S; Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
  • Richter M; Department of Cardiac Surgery, Kerckhoff-Clinic, Bad Nauheim, Germany.
  • Ganceva N; Department of Anesthesiology and Intensive Care, Kerckoff-Clinic, Bad Nauheim, Germany.
  • Sasko B; Medical Department II, Marien Hospital Herne, Ruhr-University of Bochum, Germany.
  • Giannakopoulos T; Department of Cardiology, University Hospital Brandenburg, Brandenburg an der Havel, Germany.
  • Ritter O; Faculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.
  • Szalay Z; Department of Cardiology, University Hospital Brandenburg, Brandenburg an der Havel, Germany.
  • Pagonas N; Department of Cardiac Surgery, Kerckhoff-Clinic, Bad Nauheim, Germany.
Int J Cardiol Heart Vasc ; 50: 101327, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38419608
ABSTRACT
Background and

aim:

Atrial fibrosis is an important factor in initiating and maintaining atrial fibrillation (AF). Collagen V belongs to fibrillar collagens. There are, however no data on collagen V in AF. The aim of this work was to study the quantity of collagen V and its relationship with the number of fibroblasts and TGF- b 1 expression in patients in sinus rhythm (SR) and in patients with atrial fibrillation (AF).

Methods:

We used quantitative immuhistochemistry to study collagen V in right and left atrial biopsies obtained from 35 patients in SR, 35 patients with paroxysmal AF (pAF) and 27 patients with chronic, long-standing persistent AF (cAF). In addition, we have quantified the number of vimentin-positive fibroblasts and expression levels of TGF-ß1.

Results:

Compared to patients in SR, collagen V was increased 1.8- and 3.1-fold in patients with pAF and cAF, respectively. In comparison with SR patients, the number of vimentin-positive cells increased significantly 1.46- and 1.8-fold in pAF and cAF patients, respectively.Compared to SR patients, expression levels of TGF-ß1, expressed as fluorescence units per tissue area, was significantly increased by 77 % and 300 % in patients with pAF and cAF, respectively. Similar to intensity measurements, the number of TGFß1-positive cells per 1 mm2 atrial tissue increased significantly from 35.5 ± 5.5 cells in SR patients to 61.9 ± 12.4 cells in pAF and 131.5 ± 23.5 cells in cAF. In both types of measurements, there was a statistically significant difference between pAF and cAF groups.

Conclusions:

This is the first study to show that AF is associated with increased expression levels of collagen V and TGF-ß1indicating its role in the pathogenesis of atrial fibrosis. In addition, increases in collagen V correlate with increased number of fibroblasts and TGF-ß1 and are more pronounced in cAF patients than those in pAF patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Cardiol Heart Vasc Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Cardiol Heart Vasc Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Irlanda