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Critical Aggregation Concentration Can be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides with Different Hydrophobic Tails.
Zanganeh, Saeed; Firoozpour, Loghman; Salavatipour, Maryam Samareh; Sardari, Soroush; Cohan, Reza Ahangari; Mohajel, Nasir.
Afiliación
  • Zanganeh S; Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran 1316943551, Iran.
  • Firoozpour L; Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design & Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417614411, Iran.
  • Salavatipour MS; Stem Cells and Regenerative Medicine Innovation Center Kerman University of Medical Sciences Kerman, Iran.
  • Sardari S; Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran 1316943551, Iran.
  • Cohan RA; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran 1316943551, Iran. Electronic address: cohan_r@pasteur.ac.ir.
  • Mohajel N; Department of Molecular Virology, Pasteur Institute of Iran, Tehran 1316943551, Iran. Electronic address: n_mohajel@pasteur.ac.ir.
J Pharm Sci ; 113(8): 2188-2197, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38417791
ABSTRACT
Amphiphilic peptides hold great potential as drug delivery systems. A popular peptide design approach has been to place amino acids in the peptide sequence based on their known properties. On the other hand, the directed discovery approach aims to screen a sequence space for a desired property. However, screening amphiphilic peptides for desirable drug delivery properties is not possible without a quantity that is predictive of these properties. We studied the predictive power of critical aggregation concentration (CAC) values on the drug delivery performance of a series of amphiphilic peptides with different hydrophobic tails and close CAC values. The CAC values were predicted by our previously developed model and doxorubicin was used as a model hydrophobic drug. All peptides showed close drug loading, entrapment efficiency, and release profile. They also formed similar spherical particles by assembling in reverse ß-sheet arrangements regardless of drug presence. Moreover, the assembled particles were able to accumulate doxorubicin inside ordinary as well as drug-resistant breast cancer cells and enhance its toxicity up to 39 and 17 folds, respectively. It can be concluded that similar drug delivery properties displayed by the peptides can be attributed to their similar hydrophilic-lipophilic balance as reflected in their close CAC values.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Doxorrubicina / Sistemas de Liberación de Medicamentos / Interacciones Hidrofóbicas e Hidrofílicas Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Doxorrubicina / Sistemas de Liberación de Medicamentos / Interacciones Hidrofóbicas e Hidrofílicas Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos