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Risk of Corneal Graft Rejection and Vaccination: A Matched Case-Control Study From a United States Integrated Health Care System.
Ku, Jennifer H; Nanji, Afshan A; Tubert, Julia E; Joe, Cynthia; Srikumaran, Divya; Winthrop, Kevin L; Brunton, Amanda E; Florea, Ana; Fraunfelder, Frederick; Tseng, Tsaiyu; Luo, Y I.
Afiliación
  • Ku JH; From the Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA. Electronic address: jen.h.ku@kp.org.
  • Nanji AA; Department of Ophthalmology (A.N., F.F.), Oregon Health & Science University, Portland, Oregon, USA.
  • Tubert JE; From the Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA.
  • Joe C; From the Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA.
  • Srikumaran D; Department of Ophthalmology (D.S.), Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Winthrop KL; Oregon Health & Science University-Portland State University (K.W., A.B.), School of Public Health, Portland, Oregon, USA; Division of Infectious Diseases (K.W.), Oregon Health & Science University, Portland, Oregon, USA.
  • Brunton AE; Oregon Health & Science University-Portland State University (K.W., A.B.), School of Public Health, Portland, Oregon, USA.
  • Florea A; From the Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA.
  • Fraunfelder F; Department of Ophthalmology (A.N., F.F.), Oregon Health & Science University, Portland, Oregon, USA.
  • Tseng T; From the Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA; Department of Biostatistics, School of Public Health (T.T.), University of California, Los Angeles, Westwood, California, USA.
  • Luo YI; From the Department of Research & Evaluation (J.K., J.T., C.J., A.F., Y.L.), Kaiser Permanente Southern California, Pasadena, California, USA.
Am J Ophthalmol ; 263: 133-140, 2024 07.
Article en En | MEDLINE | ID: mdl-38417569
ABSTRACT

PURPOSE:

Data on vaccine-associated corneal transplant rejections are limited. We examined the association between graft rejection and vaccination.

DESIGN:

Matched case-control

METHODS:

We used electronic health records to identify corneal transplant recipients between January 2008 and August 2022 at Kaiser Permanente Southern California. Cases were transplant recipients who experienced a graft rejection (outcome) during the study period. Randomly selected controls who did not experience a corneal graft rejection at their matched cases' index date (rejection date) were matched in a 31 ratio to cases. For controls, index date was determined by adding the number of days between transplant and graft rejection of their matched case to the control's transplant date.

RESULTS:

The study included 601 cases and 1803 matched controls (mean age 66 years [s.d. 17.0], 52% female, 47% non-Hispanic white). Twenty-three% of cases and 22% of controls received ≥1 vaccinations within 12 weeks prior to the index date. The adjusted odds ratio (aOR) for vaccination in the 12 weeks prior to index date, comparing cases to controls was 1.17 (95% CI 0.91, 1.50]). The aOR was 1.09 (0.84, 1.43) for 1 vaccination, 1.53 (0.90, 2.61) for 2 vaccinations, and 1.79 (0.55, 5.57) for ≥3 vaccinations. The aOR was 1.60 (0.81, 3.14) for mRNA vaccines, and 1.19 (0.80, 1.78) for adjuvanted/high dose vaccines.

CONCLUSIONS:

We found no evidence to suggest an association between vaccination and graft rejection. Our findings provide support for the completion of recommended vaccinations for corneal transplant recipients, without significantly increasing the risk of graft rejection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunación / Prestación Integrada de Atención de Salud / Rechazo de Injerto Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Ophthalmol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunación / Prestación Integrada de Atención de Salud / Rechazo de Injerto Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Ophthalmol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos