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Errors in Conduct of the CNBSS Trials of Breast Cancer Screening Observed by Research Personnel.
Seely, Jean M; Eby, Peter R; Gordon, Paula B; Appavoo, Shushiela; Yaffe, Martin J.
Afiliación
  • Seely JM; University of Ottawa, Department of Radiology, Ottawa, ON, Canada.
  • Eby PR; The Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
  • Gordon PB; University of Washington Virginia Mason Medical Center, Department of Radiology, WA, USA.
  • Appavoo S; University of British Columbia, Department of Radiology, Vancouver, BC, Canada.
  • Yaffe MJ; University of Alberta, Department of Diagnostic Imaging, Edmonton, Alberta, Canada.
J Breast Imaging ; 4(2): 135-143, 2022 Apr 15.
Article en En | MEDLINE | ID: mdl-38417008
ABSTRACT

OBJECTIVE:

To investigate why the Canadian National Breast Screening Study (CNBSS) did not show mortality reduction with mammography. This study explored long-standing concerns related to the validity of the randomization process, methods of recruiting women to participate in the trials, and training of the staff working in the CNBSS.

METHODS:

Surviving former CNBSS personnel, whose roles involved direct recruitment, enrollment, randomization, clinical examination, image interpretation, and management of patients in the CNBSS were interviewed. Individuals were contacted and consented to provide firsthand accounts of daily operations and adherence to research protocols via standardized questions. Consistency of observational data with quantitative results from the CNBSS trials was evaluated.

RESULTS:

Eleven of 28 (39.3%) staff confirmed that women with preexisting symptoms of breast cancer were systematically recruited at some centers; 57.1% (16/28) confirmed that personnel performing screening in CNBSS had very limited training and experience; 39.3% (11/28) verified that imaging equipment was often substandard; 50% (14/28) indicated that mammography image quality was generally poor; and 28.6% (8/28) corroborated that in some cases surgeons were unwilling to perform biopsies or surgeries for women with suspicious abnormalities found only on screening mammography that lacked a palpable correlate.

CONCLUSION:

These firsthand accounts provide new information confirming that the CNBSS did not consistently and rigorously assess the true efficacy of screening mammography. The staff accounts clarify reasons why the CNBSS results were outliers compared with the six other randomized trials of screening mammography and should not be used as credible scientific evidence to inform health policy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Breast Imaging Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Breast Imaging Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos