Your browser doesn't support javascript.
loading
Transcriptomic Insights into Metabolism-Dependent Biosynthesis of Bacterial Nanocellulose.
Wu, Qi-Zhong; Lin, Wei-Qiang; Wu, Jian-Yu; Cao, Li-Wen; Li, Hui-Hui; Gao, Rui; Du, Wen-Zheng; Sheng, Guo-Ping; Chen, Yin-Guang; Li, Wen-Wei.
Afiliación
  • Wu QZ; School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
  • Lin WQ; Sustainable Energy and Environmental Materials Innovation Center, Suzhou Institute for Advanced Research of USTC, Suzhou 215123, China.
  • Wu JY; School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
  • Cao LW; Sustainable Energy and Environmental Materials Innovation Center, Suzhou Institute for Advanced Research of USTC, Suzhou 215123, China.
  • Li HH; CAS Key Laboratory of Urban Pollutant Conversion, Department of Environmental Science and Engineering, University of Science and Technology of China, Hefei 230026, China.
  • Gao R; School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
  • Du WZ; School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
  • Sheng GP; Sustainable Energy and Environmental Materials Innovation Center, Suzhou Institute for Advanced Research of USTC, Suzhou 215123, China.
  • Chen YG; Sustainable Energy and Environmental Materials Innovation Center, Suzhou Institute for Advanced Research of USTC, Suzhou 215123, China.
  • Li WW; School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
ACS Appl Bio Mater ; 7(3): 1801-1809, 2024 03 18.
Article en En | MEDLINE | ID: mdl-38416780
ABSTRACT
Bacterial nanocellulose (BNC) is an attractive green-synthesized biomaterial for biomedical applications and various other applications. However, effective engineering of BNC production has been limited by our poor knowledge of the related metabolic processes. In contrast to the traditional perception that genome critically determines biosynthesis behaviors, here we discover that the glucose metabolism could also drastically affect the BNC synthesis in Gluconacetobacter hansenii. The transcriptomic profiles of two model BNC-producing strains, G. hansenii ATCC 53582 and ATCC 23769, which have highly similar genomes but drastically different BNC yields, were compared. The results show that their BNC synthesis capacities were highly related to metabolic activities such as ATP synthesis, ion transport protein assembly, and carbohydrate metabolic processes, confirming an important role of metabolism-related transcriptomes in governing the BNC yield. Our findings provide insights into the microbial biosynthesis behaviors from a transcriptome perspective, potentially guiding cellular engineering for biomaterial synthesis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perfilación de la Expresión Génica / Transcriptoma Idioma: En Revista: ACS Appl Bio Mater Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perfilación de la Expresión Génica / Transcriptoma Idioma: En Revista: ACS Appl Bio Mater Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos