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Genetic determinants of SARS-CoV-2 and the clinical outcome of COVID-19 in Southern Bangladesh.
Hasan, Md Mahbub; Saha, Chayan Kumar; Hamidullah Mehedi, H M; Chakma, Kallyan; Salauddin, Asma; Hossain, Md Shakhawat; Sharmen, Farjana; Rafiqul Islam, S M; Tanni, Afroza Akter; Yasmin, Farhana; Akash, Al-Shahriar; Hossain, Mohammad Enayet; Miah, Mojnu; Biswas, Sanjoy Kanti; Sultana, Nahid; Mannan, Adnan.
Afiliación
  • Hasan MM; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
  • Saha CK; Next Generation Sequencing, Research and Innovation Laboratory Chittagong (NRICh), Biotechnology Research and Innovation Center (BRIC), University of Chittagong, Chattogram, Bangladesh.
  • Hamidullah Mehedi HM; Bionamic AB, Lund, Sweden.
  • Chakma K; Department of Medicine, 250 Bedded General Hospital, Chattogram, Bangladesh.
  • Salauddin A; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
  • Hossain MS; Next Generation Sequencing, Research and Innovation Laboratory Chittagong (NRICh), Biotechnology Research and Innovation Center (BRIC), University of Chittagong, Chattogram, Bangladesh.
  • Sharmen F; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
  • Rafiqul Islam SM; Next Generation Sequencing, Research and Innovation Laboratory Chittagong (NRICh), Biotechnology Research and Innovation Center (BRIC), University of Chittagong, Chattogram, Bangladesh.
  • Tanni AA; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Yasmin F; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
  • Akash AS; Next Generation Sequencing, Research and Innovation Laboratory Chittagong (NRICh), Biotechnology Research and Innovation Center (BRIC), University of Chittagong, Chattogram, Bangladesh.
  • Hossain ME; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
  • Miah M; Next Generation Sequencing, Research and Innovation Laboratory Chittagong (NRICh), Biotechnology Research and Innovation Center (BRIC), University of Chittagong, Chattogram, Bangladesh.
  • Biswas SK; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
  • Sultana N; Next Generation Sequencing, Research and Innovation Laboratory Chittagong (NRICh), Biotechnology Research and Innovation Center (BRIC), University of Chittagong, Chattogram, Bangladesh.
  • Mannan A; Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, Bangladesh.
Immun Inflamm Dis ; 12(2): e1171, 2024 Feb.
Article en En | MEDLINE | ID: mdl-38415978
ABSTRACT

BACKGROUND:

The coronavirus disease 2019 (COVID-19) pandemic has had a severe impact on population health. The genetic determinants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in southern Bangladesh are not well understood.

METHODS:

This study aimed to determine the genomic variation in SARS-CoV-2 genomes that have evolved over 2 years of the pandemic in southern Bangladesh and their association with disease outcomes and virulence of this virus. We investigated demographic variables, disease outcomes of COVID-19 patients and genomic features of SARS-CoV-2.

RESULTS:

We observed that the disease severity was significantly higher in adults (85.3%) than in children (14.7%), because the expression of angiotensin-converting enzyme-2 (ACE-2) diminishes with ageing that causes differences in innate and adaptive immunity. The clade GK (n = 66) was remarkable between June 2021 and January 2022. Because of the mutation burden, another clade, GRA started a newly separated clustering in December 2021. The burden was significantly higher in GRA (1.5-fold) highlighted in mild symptoms of COVID-19 patients than in other clades (GH, GK, and GR). Mutations were accumulated mainly in S (22.15 mutations per segment) and ORF1ab segments. Missense (67.5%) and synonymous (18.31%) mutations were highly noticed in adult patients with mild cases rather than severe cases, especially in ORF1ab segments. Moreover, we observed many unique mutations in S protein in mild cases compared to severe, and homology modeling revealed that those might cause more folding in the protein's alpha helix and beta sheets.

CONCLUSION:

Our study identifies some risk factors such as age comorbidities (diabetes, hypertension, and renal disease) that are associated with severe COVID-19, providing valuable insight regarding prioritizing vaccination for high-risk individuals and allocating health care and resources. The findings of this work outlined the knowledge and mutational basis of SARS-CoV-2 for the next treatment steps. Further studies are needed to confirm the effects of structural and functional proteins of SARS-CoV-2 in detail for monitoring the emergence of new variants in future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Adult / Child / Humans País/Región como asunto: Asia Idioma: En Revista: Immun Inflamm Dis Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Adult / Child / Humans País/Región como asunto: Asia Idioma: En Revista: Immun Inflamm Dis Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Reino Unido