Your browser doesn't support javascript.
loading
The effect of emulgel preparation on the stability of Kojic acid in the topical anti-hyperpigmentation products.
Khadivi, Yousef; Shakeri, Saina; Arjmandmazidi, Shiva; Shokri, Javad; Monajjemzadeh, Farnaz.
Afiliación
  • Khadivi Y; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shakeri S; Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Arjmandmazidi S; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shokri J; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Monajjemzadeh F; Dermatology & Dermopharmacy Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cosmet Dermatol ; 23(6): 2145-2155, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38415395
ABSTRACT

BACKGROUND:

The emulgel, a novel drug delivery system, merges emulsion and gel, offering advantages like enhanced stability, precise control over drug release kinetics, and increased drug absorption compared to emulsions alone. Kojic acid (KA) demonstrates potent inhibition of the tyrosinase enzyme, a crucial player in the melanin synthesis pathway.

AIMS:

The main objective of this experimental study is to formulate KA within an emulgel framework and assess its stability under various environmental conditions.

METHODS:

One percent of KA emulgel and 1% simple gel, serving as the control product, were supplemented with varying concentrations of sodium metabisulfite (SMBS) for its antioxidant properties. The formulations were segregated into four groups and subjected to diverse maintenance and stress conditions over a three-month period. Monthly evaluations of physicochemical alterations were conducted, initially employing digital photography, followed by the extraction of KA and subsequent quantification of its concentration through high performance liquid chromatography (HPLC).

RESULTS:

The best formulations for retaining KA among the prepared ones were the 0.25% SMBS KA emulgel and the 0.1% SMBS KA simple gel, capable of retaining 86% and 76% of the initial KA content under stress conditions, respectively (p < 0.0001).

CONCLUSIONS:

Regarding to this study, ideal storage condition for KA emulgel and simple gel is in the refrigerator temperatures. Moreover, optimal SMBS concentrations for stability enhancement are 0.25% for emulgel and 0.1% for the simple gel. A significant statistical difference was observed between refrigerated emulgel and simple gel in the retention of KA in the presence of optimum concentration of antioxidants (p < 0.0001).
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pironas / Estabilidad de Medicamentos / Emulsiones / Geles Límite: Humans Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pironas / Estabilidad de Medicamentos / Emulsiones / Geles Límite: Humans Idioma: En Revista: J Cosmet Dermatol Asunto de la revista: DERMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido