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Use of rhodamine B as a biomarker in a simulated oral vaccine deployment against bovine tuberculosis in white-tailed deer.
Dressel, David; VerCauteren, Kurt C; Lavelle, Michael J; Snow, Nathan P; Campa, Henry.
Afiliación
  • Dressel D; Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, United States.
  • VerCauteren KC; USDA APHIS WS National Wildlife Research Center, Fort Collins, CO, United States.
  • Lavelle MJ; USDA APHIS WS National Wildlife Research Center, Fort Collins, CO, United States.
  • Snow NP; USDA APHIS WS National Wildlife Research Center, Fort Collins, CO, United States.
  • Campa H; Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI, United States.
Front Vet Sci ; 11: 1354772, 2024.
Article en En | MEDLINE | ID: mdl-38414651
ABSTRACT

Introduction:

Free-ranging white-tailed deer (Odocoileus virginianus) in northeastern lower Michigan, (United States) are a self-sustaining reservoir for bovine tuberculosis (bTB). Farm mitigation practices, baiting bans, and antlerless deer harvests have been ineffective in eliminating bTB in white-tailed deer and risks to cattle. The apparent prevalence has remained relatively constant in deer, prompting interest among wildlife researchers, managers, and veterinarians for an effective means of vaccinating deer against bTB. The commonly used human vaccine for bTB, Bacillus Calmette Guerin (BCG), is the primary candidate with oral delivery being the logical means for vaccinating deer. Materials and

methods:

We developed vaccine delivery units and incorporated the biomarker Rhodamine B before delivering them to deer to assess the level of coverage achievable. Following deployment of Rhodamine B-laden vaccine delivery units on 17 agricultural study sites in Alpena County, MI in Mar/Apr 2016, we sampled deer to detect evidence of Rhodamine B consumption. Results and

discussion:

We collected a total of 116 deer and sampled them for vibrissae/rumen marking and found 66.3% (n = 77) of the deer collected exhibited evidence of vaccine delivery unit consumption. Understanding the level of coverage we achieved with oral delivery of a biomarker in vaccine delivery units to deer enables natural resource professionals to forecast expectations of a next step toward further minimizing bTB in deer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Vet Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza