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Systematic review on intentional non-medical fentanyl use among people who use drugs.
Tsang, Vivian W L; Wong, James S H; Westenberg, Jean N; Ramadhan, Noor H; Fadakar, Hasti; Nikoo, Mohammadali; Li, Victor W; Mathew, Nick; Azar, Pouya; Jang, Kerry L; Krausz, Reinhard M.
Afiliación
  • Tsang VWL; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Wong JSH; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Westenberg JN; Complex Pain and Addiction Service, Vancouver General Hospital, Vancouver, BC, Canada.
  • Ramadhan NH; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Fadakar H; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Nikoo M; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Li VW; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Mathew N; Complex Pain and Addiction Service, Vancouver General Hospital, Vancouver, BC, Canada.
  • Azar P; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
  • Jang KL; Complex Pain and Addiction Service, Vancouver General Hospital, Vancouver, BC, Canada.
  • Krausz RM; Department of Psychiatry, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Front Psychiatry ; 15: 1347678, 2024.
Article en En | MEDLINE | ID: mdl-38414500
ABSTRACT

Objectives:

Fentanyl is a highly potent opioid and has, until recently, been considered an unwanted contaminant in the street drug supply among people who use drugs (PWUD). However, it has become a drug of choice for an increasing number of individuals. This systematic review evaluated intentional non-medical fentanyl use among PWUD, specifically by summarizing demographic variance, reasons for use, and resulting patterns of use.

Methods:

The search strategy was developed with a combination of free text keywords and MeSH and non-MeSH keywords, and adapted with database-specific filters to Ovid MEDLINE, Embase, Web of Science, and PsychINFO. Studies included were human studies with intentional use of non-medical fentanyl or analogues in individuals older than 13. Only peer-reviewed original articles available in English were included.

Results:

The search resulted in 4437 studies after de-duplication, of which 132 were selected for full-text review. Out of 41 papers included, it was found that individuals who use fentanyl intentionally were more likely to be young, male, and White. They were also more likely to have experienced overdoses, and report injection drug use. There is evidence that fentanyl seeking behaviours are motivated by greater potency, delay of withdrawal, lower cost, and greater availability.

Conclusions:

Among PWUD, individuals who intentionally use fentanyl have severe substance use patterns, precarious living situations, and extensive overdose history. In response to the increasing number of individuals who use fentanyl, alternative treatment approaches need to be developed for more effective management of withdrawal and opioid use disorder. Systematic review registration https//www.crd.york.ac.uk/prospero/, identifier CRD42021272111.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza