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The relationship of the tertiary lymphoid structures with the tumor-infiltrating lymphocytes and its prognostic value in gastric cancer.
Zhang, Nana; Zhang, Guanjun; Wang, Depu; Liu, Hao; Zhang, Yuchi; Ayarick, Vivian Adiila; Han, Xuan; Lv, Yi; Wang, Yili.
Afiliación
  • Zhang N; Center for Regenerative and Reconstructive Medicine, Med-X Institute of Western China Science and Technology Innovation Harbour, The First Affiliated Hospital of Xian JiaoTong University, China.
  • Zhang G; National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Wang D; Institute for Cancer Research School of Basic Medical Science of Xi'an Jiaotong University, China.
  • Liu H; Institute for Cancer Research School of Basic Medical Science of Xi'an Jiaotong University, China.
  • Zhang Y; Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Ayarick VA; Institute for Cancer Research School of Basic Medical Science of Xi'an Jiaotong University, China.
  • Han X; Department of Science and Technology, The First Affiliated Hospital of Xi'an Jiaotong University, China.
  • Lv Y; Center for Regenerative and Reconstructive Medicine, Med-X Institute of Western China Science and Technology Innovation Harbour, The First Affiliated Hospital of Xian JiaoTong University, China.
  • Wang Y; National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, China.
Arch Med Sci ; 20(1): 255-266, 2024.
Article en En | MEDLINE | ID: mdl-38414448
ABSTRACT

Introduction:

To explore the relationship between the tertiary lymphoid structures (TLSs) and tumor-infiltrating lymphocytes (TILs), and their distribution characteristics as well as the prognostic value in gastric cancer (GC). Material and

methods:

The TLSs and four subtypes of TILs were assessed by immunohistochemical (IHC) staining. The presence of MECA-79 positive high endothelial venules (HEVs) identified among the ectopic lymphocyte aggregation area in the GC tissue was defined as valid TLSs. The number of labeled TILs was observed in 5 fields of the most positive cells in the tumor center, invasive edge and within the TLSs, at a field of vision ×40.

Results:

The TLS distribution was significantly higher in the tumor invasive edge than the tumor center (p < 0.001). Similarly, the infiltrating density of CD8+ T cells and GrB+ T cells was statistically significantly higher in the tumor infiltrating edge than the tumor center. The total number of TILs and FOXP3+ T cells showed a contrary distribution. There was a positive correlation of the density of TLSs and TILs with both the location and the immune phenotype. A higher frequency of TILs and TLSs is often associated with favorable clinicopathologic parameters. Higher numbers of peri-TLSs (p = 0.007), peri-CD8+ (p = 0.019) and peri-GrB+TILs (p = 0.032) were significantly correlated with the favorable overall survival. Multivariate analysis revealed that the densities of TILs (p = 0.019) and TLSs (p = 0.037) were independent prognostic predictor for GC patients.

Conclusions:

We provide evidence that TLSs were positively associated with lymphocyte infiltration in GC. Thus, the formation of TLSs predicts advantageous immune system function and can be considered as a novel biomarker to stratify the overall survival risk of untreated GC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Med Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arch Med Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Polonia