Recent Developments in the Syntheses of C-20-Oxygenated ent-Kaurane Diterpenoids.
Chempluschem
; 89(6): e202300676, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38414152
ABSTRACT
Ent-kaurane diterpenes are a large group of natural products, with more than 1,000 compounds since their discovery. Due to their excellent biological activities and complex polycyclic structures, these compounds have attracted organic synthesis chemists around the world to be devoted to achieve their total synthesis. At present, the isolated C-20-oxygenated ent-kaurane diterpenes are the most abundant of these natural products, reaching more than 350 in number. However, only total syntheses of 3,20-epoxy, 7,20-epoxy and 19,20-lactone ent-kaurane diterpenes have been reported. In this review, we elaborate the synthesis of these three types of C-20 oxygenated ent-kaurane natural products, discuss these synthetic strategies in detail, and provide good guidance and reference for the synthesis of other C-20 oxygenated compounds.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diterpenos de Tipo Kaurano
Idioma:
En
Revista:
Chempluschem
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Alemania