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Distinct uric acid trajectories are associated with incident cardiac conduction block.
Li, Na; Cui, Liufu; Shu, Rong; Song, Haicheng; Wang, Jierui; Chen, Shuohua; Tse, Gary; Zhang, Nan; Yang, Xuemei; Xu, Wenqi; Wu, Shouling; Liu, Tong.
Afiliación
  • Li N; Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, No. 23, Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
  • Cui L; Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
  • Shu R; Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
  • Song H; Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
  • Wang J; Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
  • Chen S; Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
  • Tse G; Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
  • Zhang N; Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, No. 23, Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
  • Yang X; School of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, China.
  • Xu W; Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, No. 23, Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
  • Wu S; School of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei, China.
  • Liu T; Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China.
Arthritis Res Ther ; 26(1): 59, 2024 Feb 27.
Article en En | MEDLINE | ID: mdl-38413980
ABSTRACT

BACKGROUND:

The association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block.

METHODS:

A total of 67,095 participants with a mean age of 53.12 years were included from the Kailuan cohort in Tangshan, China, who were free of cardiac conduction block and with repeated measurements of UA from 2006 to 2012. UA trajectories during 2006 to 2012 were identified by group-based trajectory modeling. Cox proportional hazard regression models were used to assess the association of UA trajectories with cardiac conduction block.

RESULTS:

We categorized three observed discrete trajectories of UA during 2006-2012 period low-stable, moderate-stable, and high-stable. Over a median follow-up of 6.19 years, we identified 1405 (2.09%) incident cardiac conduction block. Compared to those in the low-stable trajectory, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of cardiac conduction block in the moderate-stable and high-stable trajectory were 1.30 (1.16-1.47) and 1.86 (1.56-2.22), and HRs of atrioventricular block were 1.39 (1.12-1.72) and 2.90 (2.19-3.83), and HRs of bundle branch blocks were 1.27 (1.10-1.47) and 1.43 (1.13-1.79). Notably, although the average UA level in the moderate-stable UA trajectory group is within the normal range, the risk of cardiac conduction block has increased.

CONCLUSIONS:

The moderate-stable and high-stable trajectories are associated with increased risk for new-onset cardiac conduction block. Monitoring UA trajectories may assist in identifying subpopulations at higher risk for cardiac conduction block.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Úrico Límite: Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Arthritis Res Ther Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Úrico Límite: Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Arthritis Res Ther Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido