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Assessment of vitamin status;  A, E and D in Egyptian neonates with IUGR: a cross sectional study.
Abdallah, Hanaa Reyad; Abdelrazek, Abderahman A; Youness, Eman Refaat; Orban, Hisham A; Mahmoud, Marwa A; El Sayed, Ahmed Helal; Zaki, Moushira.
Afiliación
  • Abdallah HR; Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt. hanaareyad@yahoo.com.
  • Abdelrazek AA; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Youness ER; Medical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
  • Orban HA; Medical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
  • Mahmoud MA; Medical Biochemistry Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
  • El Sayed AH; Department of Pediatrics, Faculty of Medicine for boys, Al- Azhar University, Cairo, Egypt.
  • Zaki M; Biological Anthropology Department, Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.
BMC Pediatr ; 24(1): 144, 2024 Feb 28.
Article en En | MEDLINE | ID: mdl-38413919
ABSTRACT

BACKGROUND:

Neonates with intrauterine growth retardation (IUGR) may present with fatal complications and permanent serious consequences. Vitamin status may influence fetal development. In this study we assessed vitamin A, E and D concentrations in umbilical cord blood in newborns with IUGR.

METHODS:

Maternal data were obtained. Neonatal assessment included; age of gestation calculated from last menstrual period, Ultrasound (U/S), new Ballard, Apgar scores and anthropometric measurements including; Head circumference, length and weight. WHO growth percentile curves were used. Vitamin A, E and D in cord blood samples were measured by high performance liquid chromatography (HPLC) and ELISA consecutively.

RESULTS:

A total of 86 full term newborns were enrolled in this study, 42 (48.8%) with IUGR with gestational age (33.59 ± 1.20) week by U/S and 44 (51.2%) appropriate for gestational age neonates with gestational age (38.70 ± 1.50). Ballard and Apgar scores (p < 0.05) and Z scores for weight, length and head circumference (p < 0.001) at birth were significantly lower in neonates with Intrauterine growth retardation (IUGR) than appropriate for gestational age (AGA) neonates. The levels of Vitamin A, E and D were significantly lower in the IUGR group than the AGA (p < 0.05) for all. Significant positive correlations of weight with vitamin A, and E cord blood levels were found (p < 0.05), while length was significantly positively correlated only with vitamin A (p < 0.05). Head circumference showed significant positive correlations with the three vitamins (p < 0.05) for all.

CONCLUSION:

Neonates with IUGR had significantly lower levels of Vitamin A, E and D than AGA neonates. Significant positive correlations of weight with vitamin A, and E cord blood levels was detected, while neonatal length was associated only with vitamin A level. The present study highlights the significance of nutritional policies for inhibiting deficiency of these vitamins during pregnancy and childhood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitaminas / Retardo del Crecimiento Fetal Límite: Child / Female / Humans / Infant / Newborn / Pregnancy País/Región como asunto: Africa Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitaminas / Retardo del Crecimiento Fetal Límite: Child / Female / Humans / Infant / Newborn / Pregnancy País/Región como asunto: Africa Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido