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Endogenous chondroitin extends the lifespan and healthspan in C. elegans.
Shibata, Yukimasa; Tanaka, Yuri; Sasakura, Hiroyuki; Morioka, Yuki; Sassa, Toshihiro; Fujii, Shion; Mitsuzumi, Kaito; Ikeno, Masashi; Kubota, Yukihiko; Kimura, Kenji; Toyoda, Hidenao; Takeuchi, Kosei; Nishiwaki, Kiyoji.
Afiliación
  • Shibata Y; Department of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan. yukshibata@kwansei.ac.jp.
  • Tanaka Y; Department of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
  • Sasakura H; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
  • Morioka Y; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
  • Sassa T; RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan.
  • Fujii S; Department of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
  • Mitsuzumi K; Department of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
  • Ikeno M; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
  • Kubota Y; Department of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
  • Kimura K; Department of Bioinformatics, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
  • Toyoda H; Department of Biomedical Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo, 669-1330, Japan.
  • Takeuchi K; Laboratory of Bio-Analytical Chemistry, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
  • Nishiwaki K; Department of Medical Cell Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Sci Rep ; 14(1): 4813, 2024 02 27.
Article en En | MEDLINE | ID: mdl-38413743
ABSTRACT
Chondroitin, a class of glycosaminoglycan polysaccharides, is found as proteoglycans in the extracellular matrix, plays a crucial role in tissue morphogenesis during development and axonal regeneration. Ingestion of chondroitin prolongs the lifespan of C. elegans. However, the roles of endogenous chondroitin in regulating lifespan and healthspan mostly remain to be investigated. Here, we demonstrate that a gain-of-function mutation in MIG-22, the chondroitin polymerizing factor (ChPF), results in elevated chondroitin levels and a significant extension of both the lifespan and healthspan in C. elegans. Importantly, the remarkable longevity observed in mig-22(gf) mutants is dependent on SQV-5/chondroitin synthase (ChSy), highlighting the pivotal role of chondroitin in controlling both lifespan and healthspan. Additionally, the mig-22(gf) mutation effectively suppresses the reduced healthspan associated with the loss of MIG-17/ADAMTS metalloprotease, a crucial for factor in basement membrane (BM) remodeling. Our findings suggest that chondroitin functions in the control of healthspan downstream of MIG-17, while regulating lifespan through a pathway independent of MIG-17.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caenorhabditis elegans / Proteínas de Caenorhabditis elegans Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caenorhabditis elegans / Proteínas de Caenorhabditis elegans Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido