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Studying the correlation of inflammatory cytokines to COVID-19 disease.
Alkhattabi, Nuha A; Alharbi, Hajer M; Basabrain, Mohammad A; Al-Zahrani, Maryam H; Alghamdi, Rana A; Joharjy, Husam; Khalifa, Reham; Tarbiah, Nesrin I.
Afiliación
  • Alkhattabi NA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: naalkhattabi@kau.edu.sa.
  • Alharbi HM; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: Hsalharbi@stu.kau.edu.sa.
  • Basabrain MA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Saudi Arabia. Electronic address: Mohammad.basabrain@gmail.com.
  • Al-Zahrani MH; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: mhsalzahrani@kau.edu.sa.
  • Alghamdi RA; Department of Chemistry, Science and Art College, King Abdulaziz University, Rabigh, Saudi Arabia. Electronic address: raalghamdi3@kau.edu.sa.
  • Joharjy H; Public Health and Infection Control Department, King Abdulaziz Hospital, Ministry of Health, Jeddah, Saudi Arabia. Electronic address: hjoharjy@moh.gov.sa.
  • Khalifa R; Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Ain Shams, Egypt. Electronic address: drreham_khalifa@med.asu.edu.eg.
  • Tarbiah NI; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: ntarabah@kau.edu.sa.
Pathol Res Pract ; 255: 155215, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38412656
ABSTRACT
Extreme response of the immune system develops cytokine storm which might be crucial in the pathology of COVID-19. The research aims to evaluate the serum level of IL-6, TNF-α, and IP-10 in severe, mild, and pre-vaccinated one-dose COVID-19 patients and investigate their clinical value and effect in the disease development among different groups of patients. A total of 72 samples were collected 18 as healthy control and 54 from confirmed COVID-19 patients including 18 mild, 18 severe, and 18 pre-vaccinated (one dose). It was confirmed that the severe group of COVID-19 patients had the highest circulating IL-6, TNF- α, and IP-10. IL-6 level in mild and pre-vaccinated (one dose) was significantly lower than in severe. In conclusion, IL-6, TNF-α, and IP-10 are associated with the pathogenicity of COVID-19, furthermore, vaccination could help to control severity of the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / COVID-19 Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / COVID-19 Límite: Humans Idioma: En Revista: Pathol Res Pract Año: 2024 Tipo del documento: Article Pais de publicación: Alemania