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Insights into Early Systemic Treatment in Atopic Dermatitis: Scientific Facts and Practical Considerations.
Vakirlis, Efstratios; Gregoriou, Stamatios; Bakirtzi, Katerina; Paschou, Eleni; Tsiogka, Aikaterini; Papadimitriou, Ilias; Sotiriou, Eleni.
Afiliación
  • Vakirlis E; First Department of Dermatology and Venereology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece.
  • Gregoriou S; 1st Department of Dermatology-Venereology, Faculty of Medicine, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece. stamgreg@yahoo.gr.
  • Bakirtzi K; First Department of Dermatology and Venereology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece.
  • Paschou E; First Department of Dermatology and Venereology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece.
  • Tsiogka A; 1st Department of Dermatology-Venereology, Faculty of Medicine, National and Kapodistrian University of Athens, Andreas Sygros Hospital, Athens, Greece.
  • Papadimitriou I; First Department of Dermatology and Venereology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece.
  • Sotiriou E; First Department of Dermatology and Venereology, Aristotle University of Thessaloniki, Hospital of Skin and Venereal Diseases, Thessaloniki, Greece.
Dermatol Ther (Heidelb) ; 14(3): 563-568, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38411895
ABSTRACT
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized clinically by pruritus, and pathophysiologically by immune dysregulation, and compromised skin barrier function. While topical therapies are currently the cornerstone of AD management, especially in mild disease, recent advancements in systemic treatments and a deeper understanding of similar skin diseases, such as psoriasis, have highlighted the importance of early intervention. In this commentary, we explore the potential benefits of early systemic intervention in AD, with pruritus determining such a decision. Building on this concept, we assume that, through the timely systemic treatment that targets the immune dysregulation present in AD, the progression of the disease could be modified, improving overall patient outcomes. Early systemic intervention may minimize systemic inflammation, halting the "atopic march" and disrupting the "itch-scratch" cycle. Managing pruritus at its root could prevent secondary complications and reduce the psychosocial burden of the disease. This paradigm shift fosters a collaborative healthcare approach that empowers patients with long-term disease control strategies. In conclusion, the safety and efficacy of novel systemic treatments offer a compelling scenario for early intervention in atopic dermatitis care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Ther (Heidelb) Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Dermatol Ther (Heidelb) Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza