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Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019-2022 prospective study with cluster and network analysis.
Pesqué, David; Borrego, Leopoldo; Zaragoza-Ninet, Violeta; Sanz-Sánchez, Tatiana; Miquel-Miquel, Francisco Javier; González-Pérez, Ricardo; Silvestre, Juan Francisco; Córdoba-Guijarro, Susana; Carrascosa, José Manuel; Gatica-Ortega, María Elena; Ruiz-González, Inmaculada; Mercader-García, Pedro; Tous-Romero, Fátima; Ortiz de Frutos, Francisco Javier; Serra-Baldrich, Esther; Pastor-Nieto, María Antonia; Rodríguez-Serna, Mercedes; Sánchez-Pérez, Javier; Sánchez-Gilo, Araceli; Melé-Ninot, Gemma; Sánchez-Pedreño Guillén, Paloma; Pujol, Ramon Maria; Giménez-Arnau, Ana María.
Afiliación
  • Pesqué D; Department of Dermatology, Hospital del Mar Research Institute, Barcelona, Spain.
  • Borrego L; Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
  • Zaragoza-Ninet V; Department of Dermatology, Hospital Universitario Insular de Gran Canaria, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
  • Sanz-Sánchez T; Department of Dermatology, Hospital General Universitario de Valencia, Valencia, Spain.
  • Miquel-Miquel FJ; Department of Dermatology, Hospital Universitario Infanta Sofía, Madrid, Spain.
  • González-Pérez R; Department of Dermatology, Hospital Arnau de Vilanova de Valencia, Valencia, Spain.
  • Silvestre JF; Department of Dermatology, Hospital Universitario Araba, Universidad del País Vasco, Vitoria-Gasteiz, Spain.
  • Córdoba-Guijarro S; Department of Dermatology, Hospital General Universitario Dr Balmis, ISABIAL, Alicante, Spain.
  • Carrascosa JM; Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain.
  • Gatica-Ortega ME; Department of Dermatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain.
  • Ruiz-González I; Department of Dermatology, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.
  • Mercader-García P; Department of Dermatology, Complejo Asistencial Universitario de León (CAULE), León, Spain.
  • Tous-Romero F; Department of Dermatology, Hospital General Universitario José María Morales Meseguer, Murcia, Spain.
  • Ortiz de Frutos FJ; Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain.
  • Serra-Baldrich E; Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain.
  • Pastor-Nieto MA; Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Rodríguez-Serna M; Department of Dermatology, Hospital Universitario de Guadalajara, Guadalajara, Spain.
  • Sánchez-Pérez J; Department of Dermatology, Hospital Fundación Jiménez-Díaz, Madrid, Spain.
  • Sánchez-Gilo A; Department of Dermatology, Hospital de la Fe, Valencia, Spain.
  • Melé-Ninot G; Department of Dermatology, Hospital Universitario de La Princesa, Madrid, Spain.
  • Sánchez-Pedreño Guillén P; Department of Dermatology, Hospital Universitario Rey Juan Carlos, Móstoles, Spain.
  • Pujol RM; Department of Dermatology, Hospital Universitari Sagrat Cor, Grupo Quirónsalud, Barcelona, Spain.
  • Giménez-Arnau AM; Department of Dermatology, Hospital Virgen de la Arrixaca, Murcia, Spain.
J Eur Acad Dermatol Venereol ; 2024 Feb 27.
Article en En | MEDLINE | ID: mdl-38411353
ABSTRACT

BACKGROUND:

There is still limited clinical-practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS).

OBJECTIVES:

To determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation.

METHODS:

Prospective multicentric study (January 2019-December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC). Clinical and patch test data of polysensitized and oligosensitized patients were compared, and risk factors of PS were investigated with logistic multivariate regression. Unsupervised hierarchical clustering and network analysis were used to study allergen aggregation in PS.

RESULTS:

A total of 10,176 patients were analysed. PS was found in 844 (8.3%). Current relevance was significantly higher in polysensitized patients (p < 0.01). Risk factors for PS were atopic dermatitis (OR 1.58, 95% CI 1.24-2.02), age (≥60 years vs. ≤24 years, OR 1.75, 95% CI 1.25-2.44) and some special locations (legs vs. face OR 1.54, 95% CI 1.05-2.25, hands vs. face OR 1.46, 95% CI1.15-1.85, arms vs. face OR 1.49, 95% CI1.01-2.20, trunk vs. face OR 1.40, 95% CI1.06-1.85). Cluster and network analyses revealed specific-allergen clusters and significant associations, including allergens belonging to metals group, fragrances and botanicals group, topical drugs group, rubber allergens and biocides.

CONCLUSIONS:

This study confirms that PS is structured by discernible patterns of specific-allergen clusters and reinforces significant allergen associations in PS. Cross-reactivity and/or concomitant sensitization could explain the formation of allergen clusters in PS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido