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Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartan.
Elrashidy, Rania A; Zakaria, Esraa M; Hasan, Rehab A; Elmaghraby, Asmaa M; Hassan, Dina A; Abdelgalil, Ranya M; Abdelmohsen, Shaimaa R; Negm, Amira M; Khalil, Azza S; Eraque, Ayat M S; Ahmed, Reem M; Sabbah, Walaa S; Ahmed, Ahmed A; Ibrahim, Samah E.
Afiliación
  • Elrashidy RA; Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  • Zakaria EM; Pharmacology Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
  • Hasan RA; Histology and Cell Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Elmaghraby AM; Histology and Cell Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Hassan DA; Histology and Cell Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Abdelgalil RM; Anatomy and Embryology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Abdelmohsen SR; Anatomy and Embryology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Negm AM; Medical Physiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Khalil AS; Medical Physiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Eraque AMS; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Ahmed RM; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Sabbah WS; Anatomy and Embryology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
  • Ahmed AA; Medical Student, Faculty of Medicine, Kasr Al Ainy, Cairo University, Cairo, Egypt.
  • Ibrahim SE; Medical Physiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Redox Rep ; 29(1): 2319963, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38411133
ABSTRACT

Objectives:

Distant liver injury is a complication of renal ischemia-reperfusion (I/R) injury, which imposes mortality and economic burden. This study aimed to elucidate the cross-talk of endoplasmic reticulum (ER) stress and mitochondrial perturbations in renal I/R-induced liver injury, and the potential hepatoprotective effect of azilsartan (AZL).

Methods:

Male albino Wister rats were pre-treated with AZL (3 mg/kg/day, PO) for 7 days then a bilateral renal I/R or sham procedure was performed. Activities of liver enzymes were assessed in plasma. The structure and ultra-structure of hepatocytes were assessed by light and electron microscopy. Markers of ER stress, mitochondrial biogenesis and apoptosis were analyzed in livers of rats.

Results:

Renal ischemic rats showed higher plasma levels of liver enzymes than sham-operated rats, coupled with histological and ultra-structural alterations in hepatocytes. Mechanistically, there was up-regulation of ER stress markers and suppression of mitochondrial biogenesis-related proteins and enhanced apoptosis in livers of renal ischemic rats. These abnormalities were almost abrogated by AZL pretreatment.

Discussion:

Our findings uncovered the involvement of mitochondrial perturbations, ER stress and apoptosis in liver injury following renal I/R, and suggested AZL as a preconditioning strategy to ameliorate remote liver injury in patients susceptible to renal I/R after adequate clinical testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / Bencimidazoles / Daño por Reperfusión / Enfermedades Renales Límite: Animals / Humans / Male Idioma: En Revista: Redox Rep Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / Bencimidazoles / Daño por Reperfusión / Enfermedades Renales Límite: Animals / Humans / Male Idioma: En Revista: Redox Rep Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido