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Determination of Capillary Blood TSH and Free Thyroxine Levels Using Digital Immunoassay.
Suzuki, Nami; Takeuchi, Miki; Miyazaki, Naoko; Tanaka, Katsumasa; Utsunomiya, Sosuke; Arai, Yoshiyuki; Yoshimura, Toru; Sugino, Kiminori; Ito, Koichi; Noh, Jaeduk Yoshimura.
Afiliación
  • Suzuki N; Department of Internal Medicine, Ito Hospital, Tokyo 150-8308, Japan.
  • Takeuchi M; Diagnostic Division, Abbott Japan LLC, Matsudo, Chiba 270-2214, Japan.
  • Miyazaki N; Clinical laboratory, Ito Hospital, Tokyo 150-8308, Japan.
  • Tanaka K; Clinical laboratory, Ito Hospital, Tokyo 150-8308, Japan.
  • Utsunomiya S; Diagnostic Division, Abbott Japan LLC, Matsudo, Chiba 270-2214, Japan.
  • Arai Y; Diagnostic Division, Abbott Japan LLC, Matsudo, Chiba 270-2214, Japan.
  • Yoshimura T; Diagnostic Division, Abbott Japan LLC, Matsudo, Chiba 270-2214, Japan.
  • Sugino K; Department of Surgery, Ito Hospital, Tokyo 150-8308, Japan.
  • Ito K; Department of Surgery, Ito Hospital, Tokyo 150-8308, Japan.
  • Noh JY; Department of Internal Medicine, Ito Hospital, Tokyo 150-8308, Japan.
J Endocr Soc ; 8(4): bvae030, 2024 Feb 19.
Article en En | MEDLINE | ID: mdl-38410786
ABSTRACT

Background:

The remote performance of thyroid function blood tests is complicated because it requires blood collection.

Objective:

To compare TSH and free thyroxine (FT4) levels between capillary and venous blood and assess the adequacy of measuring each value in capillary blood.

Methods:

This prospective intervention study was conducted at Ito Hospital and was based on the clinical research method. The participants were 5 healthy female volunteers and 50 patients (41 females and 9 males) between the ages of 23 and 81 years. To measure TSH and FT4 levels in capillary and venous blood, a digital immunoassay (d-IA) method capable of measuring trace samples was used. Chemiluminescence measurements were used as controls. Values obtained for each assay system were compared using Spearman's correlation analysis. Capillary blood was collected using an autologous device (TAP II; not approved in Japan).

Results:

Capillary plasma volume obtained using TAP II was 125 µL or more in 26 cases, 25 µL to 124 µL in 24 cases, and less than 25 µL in 5 cases. Strong correlations were noted in the TSH and FT4 levels between capillary and venous blood, with correlation coefficients of rs = 0.99 and rs = 0.97, respectively.

Conclusion:

Capillary TSH and FT4 levels strongly correlate with venous blood values. Trace samples can be used in high-precision d-IA methods. These results may promote telemedicine in assessing thyroid function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Endocr Soc Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Endocr Soc Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos