Roles of SP/KLF transcription factors in odontoblast differentiation: From development to diseases.
Oral Dis
; 30(6): 3745-3760, 2024 09.
Article
en En
| MEDLINE
| ID: mdl-38409677
ABSTRACT
OBJECTIVES:
A zinc-finger transcription factor family comprising specificity proteins (SPs) and Krüppel-like factor proteins (KLFs) plays an important role in dentin development and regeneration. However, a systematic regulatory network involving SPs/KLFs in odontoblast differentiation has not yet been described. This review examined the expression patterns of SP/KLF gene family members and their current known functions and mechanisms in odontoblast differentiation, and discussed prospective research directions for further exploration of mechanisms involving the SP/KLF gene family in dentin development. MATERIALS ANDMETHODS:
Relevant literature on SP/KLF gene family members and dentin development was acquired from PubMed and Web of Science.RESULTS:
We discuss the expression patterns, functions, and related mechanisms of eight members of the SP/KLF gene family in dentin development and genetic disorders with dental problems. We also summarize current knowledge about their complementary or synergistic actions. Finally, we propose future research directions for investigating the mechanisms of dentin development.CONCLUSIONS:
The SP/KLF gene family plays a vital role in tooth development. Studying the complex complementary or synergistic interactions between SPs/KLFs is helpful for understanding the process of odontoblast differentiation. Applications of single-cell and spatial multi-omics may provide a more complete investigation of the mechanism involved in dentin development.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diferenciación Celular
/
Factores de Transcripción de Tipo Kruppel
/
Odontoblastos
Límite:
Humans
Idioma:
En
Revista:
Oral Dis
Asunto de la revista:
ODONTOLOGIA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Dinamarca