Decreased immune response in undernourished rats after air pollution exposure.
Environ Toxicol Pharmacol
; 107: 104400, 2024 Apr.
Article
en En
| MEDLINE
| ID: mdl-38408716
ABSTRACT
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using in vitro and ex vivo methods. In vitro Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1-100⯵g/ml) for 24â¯h. Ex vivo C and NGR rats were intranasally instilled with ROFA (1â¯mg/kg BW) or PBS. 24â¯h post-exposure AM were isolated and cultured. ROFA-treatment increased superoxide anion production and TNFα secretion in C-AM in vitro, though for NGR-AM this response was lower. A similar pattern was observed for TNFα and IL-6 secretion in ex vivo experiments. Regarding the antioxidant response, although NGR-AM showed increased Nrf2, after ROFA instillation an attenuated activation was observed. To conclude, chronic undernutrition altered AM response to ROFA affecting immune responsiveness to air pollutants.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desnutrición
/
Contaminantes Atmosféricos
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Contaminación del Aire
Límite:
Animals
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Child
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Humans
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos