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Resting-state fMRI is associated with trauma experiences, mood and psychosis in Afro-descendants with bipolar disorder and schizophrenia.
de Freitas, Mariélia B L; Luna, Licia P; Beatriz, Márcia; Pinto, Romulo Kunrath; Alves, Candida H Lopes; Bittencourt, Lays; Nardi, Antônio E; Oertel, Viola; Veras, André B; de Lucena, David Freitas; Alves, Gilberto Sousa.
Afiliación
  • de Freitas MBL; Federal University of Ceará, Fortaleza, Brazil.
  • Luna LP; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA.
  • Beatriz M; Neuroradiology Service, São Domingos Hospital, São Luís, Brazil; Translational Psychiatry Research Group, Federal University of Maranhão, São Luís, Brazil.
  • Pinto RK; Neuropsychiatry Service, Nina Rodrigues Hospital, São Luís, Brazil.
  • Alves CHL; Translational Psychiatry Research Group, Federal University of Maranhão, São Luís, Brazil.
  • Bittencourt L; Neuropsychiatry Service, Nina Rodrigues Hospital, São Luís, Brazil.
  • Nardi AE; Post-Graduation in Psychiatry and Mental Health (PROPSAM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • Oertel V; Department of Psychiatry, Psychosomatics, and Psychotherapy, Frankfurt Goethe University, Germany.
  • Veras AB; Post-Graduation in Psychiatry and Mental Health (PROPSAM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Lucena DF; Federal University of Ceará, Fortaleza, Brazil.
  • Alves GS; Translational Psychiatry Research Group, Federal University of Maranhão, São Luís, Brazil; Neuropsychiatry Service, Nina Rodrigues Hospital, São Luís, Brazil; Post-Graduation in Psychiatry and Mental Health (PROPSAM), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
Psychiatry Res Neuroimaging ; 340: 111766, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38408419
ABSTRACT

BACKGROUND:

Bipolar disorder (BD) and schizophrenia (SCZ) may exhibit functional abnormalities in several brain areas, including the medial temporal and prefrontal cortex and hippocampus; however, a less explored topic is how brain connectivity is linked to premorbid trauma experiences and clinical features in non-Caucasian samples of SCZ and BD.

METHODS:

Sixty-two individuals with SCZ (n = 20), BD (n = 21), and healthy controls (HC, n = 21) from indigenous and African ethnicity were submitted to clinical screening (Di-PAD), traumata experiences (ETISR-SF), cognitive and functional MRI assessment. The item psychosis/hallucinations in SCZ patients showed a negative correlation with the global efficiency (GE) in the right dorsal attention network. The items mania, irritable mood, and racing thoughts in the Di-PAD scale had a significant negative correlation with the GE in the parietal right default mode network.

CONCLUSIONS:

Differences in the activation of specific networks were associated with earlier disease onset, history of physical abuse, and more severe psychotic and mood symptoms in SCZ and BD subjects of indigenous and black ethnicity. Findings provide further evidence on SZ and BD's brain connectivity disturbances, and their clinical significance, in non-Caucasian samples.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Trastorno Bipolar Límite: Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Esquizofrenia / Trastorno Bipolar Límite: Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos