Cyclization-Carbonylation of 2-Alkynyl Primary Benzamides using p-Benzoquinone under Neutral Conditions.
J Org Chem
; 89(6): 3977-3986, 2024 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-38407947
ABSTRACT
A palladium-catalyzed cyclization-carbonylation of 2-alkynyl primary benzamides 1 afforded methyl 3-substituted 1-methoxyisoquinoline-4-carboxylates 6 in good to moderate yields. In the case of mesylate 1r, 12 was obtained directly via a cyclization-carbonylation-cyclization cascade. Compounds 6 were converted to isoquinolin-1(2H)-ones 8 in good yields under microwave irradiation. In the case of the mesylate 6q, tricyclic isoquinolinone 10 was obtained in good yield. The reactions of thiophene-2-carboxamide derivatives also proceeded well.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos