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Biocatalysis: landmark discoveries and applications in chemical synthesis.
O'Connell, Adam; Barry, Amber; Burke, Ashleigh J; Hutton, Amy E; Bell, Elizabeth L; Green, Anthony P; O'Reilly, Elaine.
Afiliación
  • O'Connell A; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. elaine.oreilly@ucd.ie.
  • Barry A; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. elaine.oreilly@ucd.ie.
  • Burke AJ; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. anthony.green@manchester.ac.uk.
  • Hutton AE; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. anthony.green@manchester.ac.uk.
  • Bell EL; Renewable Resources and Enabling Sciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA.
  • Green AP; Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK. anthony.green@manchester.ac.uk.
  • O'Reilly E; School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. elaine.oreilly@ucd.ie.
Chem Soc Rev ; 53(6): 2828-2850, 2024 Mar 18.
Article en En | MEDLINE | ID: mdl-38407834
ABSTRACT
Biocatalysis has become an important tool in chemical synthesis, allowing access to complex molecules with high levels of activity and selectivity and with low environmental impact. Key discoveries in protein engineering, bioinformatics, recombinant technology and DNA sequencing have contributed towards the rapid acceleration of the field. This tutorial review explores enzyme engineering strategies and high-throughput screening approaches that have been applied for the discovery and development of enzymes for synthetic application. Landmark developments in the field are discussed and have been carefully selected to highlight the diverse synthetic applications of enzymes within the pharmaceutical, agricultural, food and chemical industries. The design and development of artificial biocatalytic cascades is also examined. This tutorial review will give readers an insight into the landmark discoveries and milestones that have helped shape and grow this branch of catalysis since the discovery of the first enzyme.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingeniería de Proteínas Idioma: En Revista: Chem Soc Rev Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingeniería de Proteínas Idioma: En Revista: Chem Soc Rev Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido