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Helicobacter pylori upregulates circPGD and promotes development of gastric cancer.
Zhao, Wenjun; Yao, Zhendong; Cao, Jia; Liu, Yun; Zhu, Linqi; Mao, Boneng; Cui, Feilun; Shao, Shihe.
Afiliación
  • Zhao W; The Affiliated Yixing Hospital of Jiangsu University, Wuxi, 214200, Jiangsu, China.
  • Yao Z; Urology Department, The Affiliated Taizhou Second People's Hospital of Yangzhou University, Taizhou, 225500, Jiangsu, China.
  • Cao J; The Affiliated Yixing Hospital of Jiangsu University, Wuxi, 214200, Jiangsu, China.
  • Liu Y; School of Medicine, Shanghai East Hospital, Tongji University, Shanghai, 200120, China.
  • Zhu L; Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China.
  • Mao B; Jiangsu University School of Medicine, Zhenjiang, 212013, Jiangsu, China.
  • Cui F; The Affiliated Yixing Hospital of Jiangsu University, Wuxi, 214200, Jiangsu, China. staff562@yxph.com.
  • Shao S; Urology Department, The Affiliated Taizhou Second People's Hospital of Yangzhou University, Taizhou, 225500, Jiangsu, China. pdcuifeilun@163.com.
J Cancer Res Clin Oncol ; 150(2): 104, 2024 Feb 26.
Article en En | MEDLINE | ID: mdl-38407616
ABSTRACT

PURPOSE:

Helicobacter pylori (H. pylori) has unique biochemical traits and pathogenic mechanisms, which make it a substantial cause of gastrointestinal cancers. Circular RNAs (circRNAs) have concurrently been identified as an important participating factor in the pathophysiology of several different cancers. However, the underlying processes and putative interactions between H. pylori and circRNAs have received very little attention. To address this issue, we explored the interaction between H. pylori and circRNAs to investigate how they might jointly contribute to the occurrence and development of gastric cancer.

METHODS:

Changes in circPGD expression in H. pylori were detected using qRT-PCR. Cell proliferation and migration changes were assayed by colony formation, the CCK-8 assay and the transwell assay. Apoptosis was measured by flow cytometry. Western blot was conducted to detect changes in cell migration, apoptosis, proliferation and inflammation-associated proteins. QRT-PCR was used to measure changes in circPGD and inflammation-associated factors.

RESULTS:

We found that H. pylori induced increased circPGD expression in infected human cells and facilitated gastric cancer progression in three ways by promoting cell proliferation and migration, enhancing the inflammatory response, and inhibiting apoptosis.

CONCLUSIONS:

CircPGD appears to play a role in H. pylori-related gastric cancer and may thus be a viable, novel target for therapeutic intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Helicobacter pylori Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Helicobacter pylori Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania