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The effect of vitamin D on adolescents' primary dysmenorrhea.
Donayeva, Ainur; Amanzholkyzy, Ainur; Abdelazim, Ibrahim; Kurmangazin, Meirambek; Khamidullina, Zaituna; Kurmanalina, Madina; Sumanova, Aigul; Shabanbayeva, Zhanara; Baubekov, Zhenisbek; Bissaliyev, Bauyrzhan; Gubasheva, Gulnara; Samaha, Ihab.
Afiliación
  • Donayeva A; Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Amanzholkyzy A; Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Abdelazim I; Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Kurmangazin M; Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Khamidullina Z; Department of Obstetrics and Gynecology №, Astana Medical University, Astana, Kazakhstan.
  • Kurmanalina M; Department of Therapeutic and Orthopedic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Sumanova A; Department of Therapeutic and Orthopedic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Shabanbayeva Z; Department of Therapeutic and Orthopedic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Baubekov Z; Department of Pediatric Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Bissaliyev B; Department of Pediatric Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Gubasheva G; Department of Obstetrics and Gynecology №, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
  • Samaha I; Department of Obstetrics and Gynecology, Faculty of Medicine, Helwan University, Cairo, Egypt.
J Med Life ; 16(11): 1658-1662, 2023 Nov.
Article en En | MEDLINE | ID: mdl-38406787
ABSTRACT
Vitamin D receptor (VDR) expression in the female reproductive tract explains the regulatory role of vitamin D on inflammatory cytokine and prostaglandin (PGD) synthesis. This study aimed to evaluate the effect of vitamin D on adolescents' primary dysmenorrhea and the relationship between Vit. D and adolescents' primary dysmenorrhea. Eighty-five adolescents were included in the current study. After a detailed evaluation, pelvic sonography was performed for all participants to rule out any pelvic pathology. Blood samples were collected to measure thyroid stimulating hormone (TSH), prolactin, glycosylated hemoglobin (HbA1C), and 25-hydroxyvitamin D (25[OH]D). Participants were administered vitamin D (50,000 IU weekly for five months), and their dysmenorrhea symptoms were evaluated before and after this period using the Visual Analog Scale (VAS) and the Verbal Multidimensional Scoring (VMS). The mean VAS and VMS scores of dysmenorrhea statistically decreased from 8.7±0.91 and 2.65±0.93 to 4.8±0.75 and 0.80±0.75, respectively, after vitamin D intake (p=0.03 and 0.025, respectively). Significant negative associations between 25(OH)D and VAS (R = -0.886; p<0.00001) and VMS of dysmenorrhea (R = -0.885; p<0.00001) were detected in this study. Vit. D could be a useful therapeutic option to reduce the severity of primary dysmenorrhea and could limit the use of non-steroidal anti-inflammatory drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Dismenorrea Límite: Adolescent / Female / Humans Idioma: En Revista: J Med Life Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Kazajstán Pais de publicación: Rumanía
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina D / Dismenorrea Límite: Adolescent / Female / Humans Idioma: En Revista: J Med Life Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Kazajstán Pais de publicación: Rumanía