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Rapid clearing and imaging of Mohs and melanoma surgical margins using a low-cost tissue processor.
Huang, Chi Z; Montague, Jenna E; Ching-Roa, Vincent D; Drage, Michael G; Ibrahim, Sherrif F; Giacomelli, Michael G.
Afiliación
  • Huang CZ; Department of Biomedical Engineering, University of Rochester, 207 Goergen Hall, Box 270168, Rochester, NY 14627, USA.
  • Montague JE; Wyant College of Optical Sciences, University of Arizona, 1630 E University Blvd, Tucson, AZ, 85719, USA.
  • Ching-Roa VD; Department of Biomedical Engineering, University of Rochester, 207 Goergen Hall, Box 270168, Rochester, NY 14627, USA.
  • Drage MG; Department of Pathology, Mass General Brigham, 399 Revolution Drive, Somerville, MA 02145, USA.
  • Ibrahim SF; Rochester Dermatologic Surgery, PC, 7400 Pittsford Victor Rd Suite A, Victor, NY 14564, USA.
  • Giacomelli MG; Department of Dermatology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14620, USA.
Biomed Opt Express ; 15(2): 700-714, 2024 Feb 01.
Article en En | MEDLINE | ID: mdl-38404330
ABSTRACT
Tissue clearing methods render biological tissues transparent while maintaining tissue structure, enabling visualization of entire tissues. Recent developments in tissue clearing have predominantly emphasized preserving intrinsic fluorescent proteins or aqueous-based tissue clearing and so typically involve complex procedures and long processing times. The utilization of tissue clearing protocols in standard of care histology settings has been less well explored, and protocols for rapid clearing of human tissue specimens are limited. This study presents a novel rapid clearing protocol and demonstrates a low-cost tissue processor for high volume rapid tissue clearing that can be intergraded into standard histology workflow. We demonstrate rapid clearing in dermatological specimens, including both nonmelanoma and melanoma excisions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos