Your browser doesn't support javascript.
loading
Oestrogen And Progesterone Receptors' Expression Pattern In Fibro-Adenoma Of The Female Breast.
Naeem, Shagufta; Naz, Shabana; Amanullah, Khadija; Javed, Hamza; Khan, Omair; Afridi, Ehtesham Ahmed Khan; Ahmed, Sikandar.
Afiliación
  • Naeem S; Department of Pathology.
  • Naz S; Department of Pathology.
  • Amanullah K; Army Medical College NUMS, Islamabad.
  • Javed H; Pakistan Red Crescent Society, Pakistan.
  • Khan O; Department of Forensic Medicine.
  • Afridi EAK; Department of Neurosurgery.
  • Ahmed S; Student, Ayub Medical College, Abbottabad.
J Ayub Med Coll Abbottabad ; 35(3): 400-404, 2023.
Article en En | MEDLINE | ID: mdl-38404080
ABSTRACT

BACKGROUND:

Fibro-adenoma is the most common benign condition of the female breast comprising about 68% of all breast lumps. Fibroadenoma is an independent risk factor for the development of breast cancer. Complex fibroadenoma has a 2-3-fold increased risk ratio and simple fibroadenoma has 1.49 times increased risk ratio of developing cancer than the normal population over a period of 20 years. This study aimed to qualitatively check the frequency of oestrogen receptor-positive and progesterone receptor-positive cases of fibroadenoma in our region.

METHODS:

This cross-sectional study was conducted in the pathology department of Ayub Medical College, Abbottabad from June 2020 to December 2021. Biopsy confirmed cases of fibroadenoma were examined using immune-histochemical stains to score qualitatively the expression pattern of ER and PR. Data was analyzed and assessed using SPSS version 25. A p-value of ≤0.05 was considered statistically significant.

RESULTS:

The mean age of patients who presented with fibro-adenoma was 24.5±9.29 years with a median age of 21.5 years. In most cases, oestrogen receptor expression was mild 23 (54.76%) whereas progesterone receptor expression was severe 19 (45.23%). On chi-square test, the pattern of progesterone receptor expression for the category of hormone intake showed significant differences. Whereas, the pattern of oestrogen receptor expression for the categories of marital status, history of hormone intake, history of menstrual cycle and type of fibroadenoma showed no statistically significant difference.

CONCLUSIONS:

Further study into the pathogenesis of fibroadenoma is required to understand the role of ER and PR and explore the therapeutic potential of such drugs that affects these receptors. Cabling.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Adenoma / Fibroadenoma Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: J Ayub Med Coll Abbottabad Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article Pais de publicación: Pakistán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Adenoma / Fibroadenoma Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: J Ayub Med Coll Abbottabad Asunto de la revista: MEDICINA Año: 2023 Tipo del documento: Article Pais de publicación: Pakistán