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[A new benzopyran glycoside from Gentiana macrophylla].
Huang, Pei-Qi; Kang, Kai-Wen; Liao, Zi-Bin; Wen, Yan; Gan, Li-She.
Afiliación
  • Huang PQ; School of Biotechnology and Health Sciences, Wuyi University Jiangmen 529020, China.
  • Kang KW; School of Biotechnology and Health Sciences, Wuyi University Jiangmen 529020, China.
  • Liao ZB; School of Biotechnology and Health Sciences, Wuyi University Jiangmen 529020, China.
  • Wen Y; School of Biotechnology and Health Sciences, Wuyi University Jiangmen 529020, China.
  • Gan LS; School of Biotechnology and Health Sciences, Wuyi University Jiangmen 529020, China Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University Hangzhou 310058, China.
Zhongguo Zhong Yao Za Zhi ; 49(2): 412-419, 2024 Jan.
Article en Zh | MEDLINE | ID: mdl-38403317
ABSTRACT
Thirteen compounds were isolated and identified from 70% ethanol extract of the roots of Gentiana macrophylla by multi-chromatographic methods, including microporous resin, silica gel, and C_(18) reversed-phase column chromatography, as well as HPLC as follows macrophylloside G(1), macrophylloside D(2), 5-formyl-2,3-dihydroisocoumarin(3),(+)-medicarpin(4),(+)-syringaresinol(5), liquiritigenin(6),(3R)-sativanone(7),(3R)-3'-O-methylviolanone(8), 4,2',4'-trihydroxychalcone(9), latifolin(10), gentioxepine(11), 6α-hydroxycyclonerolidol(12), and ethyl linoleate(13). Compound 1 was a new benzopyran glycoside. Compounds 4, 6-10, 12, and 13 were isolated for the first time from Gentiana plants. Compounds 1 and 2 showed promising hepatoprotective activity against D-GalN-induced AML12 cell damage at the concentration of 10 µmol·L~(-1), and compound 2 exhibited more significant activity than silybin at the same concentration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicósidos Cardíacos / Gentiana / Éteres Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicósidos Cardíacos / Gentiana / Éteres Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China