Your browser doesn't support javascript.
loading
Both clinical trial register and electronic bibliographic database searches were needed to identify randomized clinical trials for systematic reviews: an evaluation study.
Kaul, Tabea; Colombijn, Julia M T; Vernooij, Robin W M; Spijker, Rene; Idema, Demy L; Huis In 't Veld, Linde F; Damen, Johanna A A; Hooft, Lotty.
Afiliación
  • Kaul T; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address: t.kaul@umcutrecht.nl.
  • Colombijn JMT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Vernooij RWM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Spijker R; Cochrane Netherlands, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Medical Library, Amsterdam, The Netherlands.
  • Idema DL; Cochrane Netherlands, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Huis In 't Veld LF; Cochrane Netherlands, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Damen JAA; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Cochrane Netherlands, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Hooft L; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Cochrane Netherlands, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
J Clin Epidemiol ; 169: 111300, 2024 May.
Article en En | MEDLINE | ID: mdl-38402998
ABSTRACT

OBJECTIVES:

To determine whether clinical trial register (CTR) searches can accurately identify a greater number of completed randomized clinical trials (RCTs) than electronic bibliographic database (EBD) searches for systematic reviews of interventions, and to quantify the number of eligible ongoing trials. STUDY DESIGN AND

SETTING:

We performed an evaluation study and based our search for RCTs on the eligibility criteria of a systematic review that focused on the underrepresentation of people with chronic kidney disease in cardiovascular RCTs. We conducted a combined search of ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform through the Cochrane Central Register of Controlled Trials to identify eligible RCTs registered up to June 1, 2023. We searched Cochrane Central Register of Controlled Trials, EMBASE, and MEDLINE for publications of eligible RCTs published up to June 5, 2023. Finally, we compared the search results to determine the extent to which the two sources identified the same RCTs.

RESULTS:

We included 92 completed RCTs. Of these, 81 had results available. Sixty-six completed RCTs with available results were identified by both sources (81% agreement [95% CI 71-88]). We identified seven completed RCTs with results exclusively by CTR search (9% [95% CI 4-17]) and eight exclusively by EBD search (10% [95% CI 5-18]). Eleven RCTs were completed but lacked results (four identified by both sources (36% [95% CI 15-65]), one exclusively by EBD search (9% [95% CI 1-38]), and six exclusively by CTR search (55% [95% CI 28-79])). Also, we identified 42 eligible ongoing RCTs 16 by both sources (38% [95% CI 25-53]) and 26 exclusively by CTR search (62% [95% CI 47-75]). Lastly, we identified four RCTs of unknown status by both sources.

CONCLUSION:

CTR searches identify a greater number of completed RCTs than EBD searches. Both searches missed some included RCTs. Based on our case study, researchers (eg, information specialists, systematic reviewers) aiming to identify all available RCTs should continue to search both sources. Once the barriers to performing CTR searches alone are targeted, CTR searches may be a suitable alternative.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Sistema de Registros / Bases de Datos Bibliográficas / Revisiones Sistemáticas como Asunto Límite: Humans Idioma: En Revista: J Clin Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos Clínicos Controlados Aleatorios como Asunto / Sistema de Registros / Bases de Datos Bibliográficas / Revisiones Sistemáticas como Asunto Límite: Humans Idioma: En Revista: J Clin Epidemiol Asunto de la revista: EPIDEMIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos