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Exploring miR-155-5p and miR-1246 as Diagnostic and Prognostic Markers in Oral Squamous cell carcinoma.
Maheswari, R; Urs, Aadithya B; Kumar, Priya; Koner, B C; Guru, Sameer Ahmad; Rawat, Garima.
Afiliación
  • Maheswari R; Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India.
  • Urs AB; Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India.
  • Kumar P; Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, MAMC Complex, Mirdard Marg, Bahadur Shah Zafar Marg, LNJP Colony, New Delhi, 110002, India. drpri_kumar@yahoo.com.
  • Koner BC; Department of Biochemistry, Maulana Azad Medical College, New Delhi, 110002, India.
  • Guru SA; Developmental Systems Biology, Ann and Lurie Children's Hospital, Northwestern University, Chicago, IL, 60611, USA.
  • Rawat G; Department of Pathology, Dharamshila Narayana Superspeciality Hospital, New Delhi, 110002, India.
Mol Biol Rep ; 51(1): 341, 2024 Feb 24.
Article en En | MEDLINE | ID: mdl-38400867
ABSTRACT

INTRODUCTION:

Oral Squamous Cell Carcinoma (OSCC) is one of the leading cancers worldwide, significantly impacting developing nations. This study aimed to explore the diagnostic and prognostic potential of miR-155-5p and miR-1246 in OSCC in the Indian population, as their comparative roles in this context remain unexplored. MATERIAL AND

METHODS:

The present cross-sectional study comprised 50 histopathologically confirmed OSCC cases, with adjacent normal mucosa as controls. MiRNA expression was assessed via qRT-PCR and correlated with clinicopathological factors. MiRwalk and miRTargetlink were used for miRNAmRNA interaction prediction, and gprofiler was employed to analyze validated targets for functional insights.

RESULTS:

The expression analysis showed a significant upregulation of miR-155-5p and miR-1246 in OSCC tissues compared to adjacent controls. Receiver operating curve analysis revealed that miR-1246 exhibited excellent diagnostic accuracy (AUC = 0.94) compared to miR-155-5p (AUC = 0.69). Higher miRNA levels were associated with age and extracapsular extension while overexpression of miR-1246 was correlated significantly with increased tumor size, tumor grade, TNM staging, and depth of invasion. The analysis for target prediction unveiled a set of validated targets, among which were WNT5A, TP53INP1, STAT3, CTNNB1, PRKAR1A, and NFIB.

CONCLUSION:

miR-155-5p and miR-1246 may be used as potential prognostic biomarkers in OSCC, with miR-1246 demonstrating superior diagnostic accuracy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / MicroARNs / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / MicroARNs / Neoplasias de Cabeza y Cuello Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos