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Exposure to per- and polyfluoroalkyl substances and breast cancer risk: a systematic review and meta-analysis of epidemiologic studies.
Chang, Che-Jung; Ish, Jennifer L; Chang, Vicky C; Daniel, Meklit; Jones, Rena R; White, Alexandra J.
Afiliación
  • Chang CJ; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
  • Ish JL; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
  • Chang VC; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, United States.
  • Daniel M; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
  • Jones RR; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, United States.
  • White AJ; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.
Am J Epidemiol ; 193(8): 1182-1196, 2024 Aug 05.
Article en En | MEDLINE | ID: mdl-38400646
ABSTRACT
We synthesized the epidemiologic evidence on the associations between per- and polyfluoroalkyl substances (PFAS) exposure and breast cancer risk. Our systematic review and meta-analysis included 18 and 11 articles, respectively, covering studies up to February 2023. The summary relative risks (RRs) estimated by random-effects meta-analyses did not support an association between PFAS and overall breast cancer risk (eg, a natural log (ln)-unit increase in serum/plasma concentrations [ng/mL] for perfluorooctanoate [PFOA] RR = 0.95; 95% CI, 0.77-1.18; perfluorooctane sulfonate [PFOS] RR = 0.98; 95% CI, 0.87-1.11). However, when limiting to studies that assessed exposures prior to a breast cancer diagnosis, we observed a positive association with PFOA (a ln-unit increase, RR = 1.16; 95% CI, 0.96-1.40). We also observed some possible heterogeneous associations by tumor estrogen and progesterone receptor status among postmenopausal breast cancer cases. No meaningful changes were observed after excluding the studies with high risk of bias (Tier 3). Based on the evaluation tool developed by the National Toxicology Program, given the heterogeneity across studies and the variability in timing of exposure measurements, the epidemiologic evidence needed to determine the association between PFAS exposure and breast cancer remains inadequate. Our findings support the need for future studies with improved study designs to determine this association.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Caprilatos / Exposición a Riesgos Ambientales / Fluorocarburos Límite: Female / Humans Idioma: En Revista: Am J Epidemiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Caprilatos / Exposición a Riesgos Ambientales / Fluorocarburos Límite: Female / Humans Idioma: En Revista: Am J Epidemiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos