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Intradermal Fractional ChAdOx1 nCoV-19 Booster Vaccine Induces Memory T Cells: A Follow-Up Study.
Sophonmanee, Ratchanon; Preampruchcha, Perawas; Ongarj, Jomkwan; Seeyankem, Bunya; Intapiboon, Porntip; Surasombatpattana, Smonrapat; Uppanisakorn, Supattra; Sangsupawanich, Pasuree; Chusri, Sarunyou; Pinpathomrat, Nawamin.
Afiliación
  • Sophonmanee R; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Preampruchcha P; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Ongarj J; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Seeyankem B; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Intapiboon P; Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Surasombatpattana S; Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Uppanisakorn S; Clinical Research Center, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Sangsupawanich P; Clinical Research Center, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Chusri S; Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
  • Pinpathomrat N; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.
Vaccines (Basel) ; 12(2)2024 Jan 23.
Article en En | MEDLINE | ID: mdl-38400093
ABSTRACT
The administration of viral vector and mRNA vaccine booster effectively induces humoral and cellular immune responses. Effector T cell responses after fractional intradermal (ID) vaccination are comparable to those after intramuscular (IM) boosters. Here, we quantified T cell responses after booster vaccination. ChAdOx1 nCoV-19 vaccination induced higher numbers of S1-specific CD8+ memory T cells, consistent with the antibody responses. Effector memory T cell phenotypes elicited by mRNA vaccination showed a similar trend to those elicited by the viral vector vaccine booster. Three months post-vaccination, cytokine responses remained detectable, confirming effector T cell responses induced by both vaccines. The ID fractional dose of ChAdOx1 nCoV-19 elicited higher effector CD8+ T cell responses than IM vaccination. This study confirmed that an ID dose-reduction vaccination strategy effectively stimulates effector memory T cell responses. ID injection could be an improved approach for effective vaccination programs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Suiza