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Silver Nanoparticles In Situ Synthesized and Incorporated in Uniaxial and Core-Shell Electrospun Nanofibers to Inhibit Coronavirus.
de Freitas, Camila F; Souza, Paulo R; Jacinto, Gislaine S; Braga, Thais L; Ricken, Yara S; Souza, Gredson K; Caetano, Wilker; Radovanovic, Eduardo; Arns, Clarice W; Rai, Mahendra; Muniz, Edvani C.
Afiliación
  • de Freitas CF; Department of Chemistry, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
  • Souza PR; Department of Chemistry, State University of Maringá, Av. Colombo, 5790, Maringá 87020-900, Brazil.
  • Jacinto GS; Department of Chemistry, State University of Maringá, Av. Colombo, 5790, Maringá 87020-900, Brazil.
  • Braga TL; Laboratory of Virology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-970, Brazil.
  • Ricken YS; Department of Chemistry, State University of Maringá, Av. Colombo, 5790, Maringá 87020-900, Brazil.
  • Souza GK; Department of Chemistry, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
  • Caetano W; Chemistry Institute, State University of Campinas, UNICAMP, Rua Josué de Castro Cidade Universitária, Campinas 13083-970, Brazil.
  • Radovanovic E; Department of Chemistry, State University of Maringá, Av. Colombo, 5790, Maringá 87020-900, Brazil.
  • Arns CW; Department of Chemistry, State University of Maringá, Av. Colombo, 5790, Maringá 87020-900, Brazil.
  • Rai M; Laboratory of Virology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-970, Brazil.
  • Muniz EC; Department of Microbiology, Nicolaus Copernicus University, 87-100 Torun, Poland.
Pharmaceutics ; 16(2)2024 Feb 14.
Article en En | MEDLINE | ID: mdl-38399322
ABSTRACT
In the present study, we sought to develop materials applicable to personal and collective protection equipment to mitigate SARS-CoV-2. For this purpose, AgNPs were synthesized and stabilized into electrospinning nanofiber matrices (NMs) consisting of poly(vinyl alcohol) (PVA), chitosan (CHT), and poly-ε-caprolactone (PCL). Uniaxial nanofibers of PVA and PVA/CHT were developed, as well as coaxial nanofibers of PCL[PVA/CHT], in which the PCL works as a shell and the blend as a core. A crucial aspect of the present study is the in situ synthesis of AgNPs using PVA as a reducing and stabilizing agent. This process presents few steps, no additional toxic reducing agents, and avoids the postloading of drugs or the posttreatment of NM use. In general, the in situ synthesized AgNPs had an average size of 11.6 nm, and the incorporated nanofibers had a diameter in the range of 300 nm, with high uniformity and low polydispersity. The NM's spectroscopic, thermal, and mechanical properties were appropriate for the intended application. Uniaxial (PVA/AgNPs and PVA/CHT/AgNPs) and coaxial (PCL[PVA/CHT/AgNPs]) NMs presented virucidal activity (log's reduction ≥ 5) against mouse hepatitis virus (MHV-3) genus Betacoronavirus strains. In addition to that, the NMs did not present cytotoxicity against fibroblast cells (L929 ATCC® CCL-1TM lineage).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza