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Long-Term Changes to the Microbiome, Blood Lipid Profiles and IL-6 in Female and Male Swedish Patients in Response to Bariatric Roux-en-Y Gastric Bypass.
Prykhodko, Olena; Burleigh, Stephen; Campanello, Magnus; Iresjö, Britt-Marie; Zilling, Thomas; Ljungh, Åsa; Smedh, Ulrika; Hållenius, Frida Fåk.
Afiliación
  • Prykhodko O; Division of Food and Pharma, Department of Process and Life Science Engineering, Faculty of Engineering, Lund University, 221 00 Lund, Sweden.
  • Burleigh S; Division of Food and Pharma, Department of Process and Life Science Engineering, Faculty of Engineering, Lund University, 221 00 Lund, Sweden.
  • Campanello M; Department of Surgery, Halland Regional Hospital Varberg, 432 81 Varberg, Sweden.
  • Iresjö BM; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, 413 45 Gothenburg, Sweden.
  • Zilling T; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, 413 45 Gothenburg, Sweden.
  • Ljungh Å; Department of Surgery, Halland Regional Hospital Varberg, 432 81 Varberg, Sweden.
  • Smedh U; Medical Faculty, Lund University, 221 00 Lund, Sweden.
  • Hållenius FF; Medical Faculty, Lund University, 221 00 Lund, Sweden.
Nutrients ; 16(4)2024 Feb 09.
Article en En | MEDLINE | ID: mdl-38398821
ABSTRACT
Lipid metabolism dysregulation is a critical factor contributing to obesity. To counteract obesity-associated disorders, bariatric surgery is implemented as a very effective method. However, surgery such as Roux-en-Y gastric bypass (RYGB) is irreversible, resulting in life-long changes to the digestive tract. The aim of the present study was to elucidate changes in the fecal microbiota before and after RYGB in relation to blood lipid profiles and proinflammatory IL-6. Here, we studied the long-term effects, up to six years after the RYGB procedure, on 15 patients' gut microbiomes and their post-surgery well-being, emphasizing the biological sex of the patients. The results showed improved health among the patients after surgery, which coincided with weight loss and improved lipid metabolism. Health changes were associated with decreased inflammation and significant alterations in the gut microbiome after surgery that differed between females and males. The Actinobacteriota phylum decreased in females and increased in males. Overall increases in the genera Prevotella, Paraprevotella, Gemella, Streptococcus, and Veillonella_A, and decreases in Bacteroides_H, Anaerostipes, Lachnoclostridium_B, Hydrogeniiclostridium, Lawsonibacter, Paludicola, and Rothia were observed. In conclusion, our findings indicate that there were long-term changes in the gut microbiota after RYGB, and shifts in the microbial taxa appeared to differ depending on sex, which should be investigated further in a larger cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Derivación Gástrica / Lactobacillales / Microbioma Gastrointestinal Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Derivación Gástrica / Lactobacillales / Microbioma Gastrointestinal Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza